Reading time: 5 min

Fasting has been part of religious and cultural traditions for centuries. Yet in recent years, nutritionists and health experts have proven that water fasting — reducing all food and drink to only H₂O for a short time — also has numerous health benefits.

Not eating for a period of time can be challenging both physically and mentally, but the short and long-term wellness benefits may outweigh the temporary discomfort. Here’s a look at what water fasting is and how it has the potential to improve a range of health conditions.

What Is Water Fasting?

Water fasting is a regimen where an individual restricts all food and drink intake except for water. Water fasting can be done for either short or long periods of time.

Some people may engage in a day fast on only water, while others water fast for three days. Health professionals don’t recommend fasting for more than five days, especially if it’s your first fast. Water fasting can also be done as part of a different fasting regimen like intermittent fasting, as standard intermittent fasting diets allow for the intake of water.

According to Frank Hu, nutrition department chair at Harvard, intermittent fasting arose from research on animals, which showed that it can lower the risk of cancer and reduce the side effects of growing older. The potential anti-aging effects of fasting are just one reason why so many people are trying out the trend.

Benefits of Water Fasting

The benefits of water fasting abound, though not all claims have been substantiated by research. Here’s a look at the proven health benefits of water fasting, including how it can support weight loss, blood sugar maintenance, and relief from a variety of health problems.

Autophagy

Autophagy is a natural bodily process by which the cells clean themselves of accumulated waste materials. Sometimes, cells remove these molecules by recycling and reusing them, and other times they eliminate these materials all together.

Autophagy has been shown to improve liver function, especially in instances of drug and alcohol-related damage. Other studies show that autophagy boosts immunity by reducing toxins in the body and clearing out potential disease-causing agents. Without autophagy, research suggests that muscle degeneration and weakness can occur.

Autophagy has also been shown to reduce inflammation, meaning it can have a potential effect on genetic and inherited diseases, as well as autoimmune diseases.

Weight Loss

Many people turn to water fasting as a quick and effective way to lose body weight. But does it really work? Research suggests yes — but only for a short amount of time.

A study on people of average weight showed that water fasting every other day increased the rate of fat oxidation, meaning it burned fat more quickly. However, these subjects were also faced with consistently high levels of hunger. This suggests that it’s more realistic to maintain this diet for a short period of time.

Blood Pressure and Diabetes

One scientific study on prediabetic men showed that intermittent fasting could help increase insulin sensitivity. Since low insulin sensitivity leads to an increase in blood sugar levels — increasing a person’s risk for type 2 diabetes — this increased sensitivity can reduce a person’s diabetes risk.

Moreover, the same study showed that intermittent fasting lowers blood pressure, helping reduce the risk of heart disease. Whether or not you’re already at risk for diabetes, such results prove that water fasting may support an increased resiliency against the condition.

Side Effects of Water Fasting

The greatest risk of anyone who water fasts is refeeding. While refeeding syndrome is rare, it can arise as a side effect of fasting for a long period of time when reintroducing food.

Refeeding syndrome is a dangerous and potentially deadly condition that happens when your body experiences dramatic, rapid changes in electrolytes and nutrients after not eating. It can cause fatigue, heart failure, dizziness, high blood pressure, seizures and, rarely, death.

Prevent Refeeding Syndrome

So how can you prevent refeeding syndrome and effectively reintroduce food post-fast? The greatest risk factors are having a preexisting eating disorder, such as anorexia nervosa, or having a history of alcoholism. People with these disorders should avoid water fasting.

Opting for a one-day juice or broth cleanse can ensure that you’re still getting nutrients in your body while enjoying the health benefits of fasting. Having been on a strict water fast for five or more days can also put you at risk of refeeding syndrome.

If you don’t have a preexisting condition that can put you at risk, minimizing your fast to 72 hours or less is the best way to prevent this condition to occur. You can also avoid breaking your fast with high-carb, high-sugar meals. Instead opt for something high in protein and fat, and maintain a steady intake of electrolytes by drinking mineral water and adding himalayan salt to your water.

Water Fasting Tips

While the rules for a water fast are relatively easy, there are a few important things to keep in mind in order to have a safe and effective experience.

Drink Enough Water

Many people who try this type of fast neglect to drink enough water throughout the day, leaving them feeling dehydrated. Since most foods contain water, reducing your food intake also reduces your overall hydration.

Snap Kitchen dietician Samantha Presicci suggests that, while the amount of water intake differs between people, women should aim to drink between two and two and a half liters of water and men should try to drink three liters during a water fast.

Presicci adds that it’s a good idea to incorporate water into your daily schedule to ensure you’re drinking enough throughout the day. Reaching for water during regular meal times will keep you hydrated while warding off headaches, bloating, and hunger related to the lack of food intake.

Balance Electrolytes

Research shows that individuals who water fast experience depletion of crucial nutrients like potassium and sodium.

Since potassium and sodium are essential for staying hydrated and maintaining proper organ function, anyone water fasting for a prolonged period of time may want to consider ingesting some whole foods to maintain balance. Eating a small amount of food, like fruits, vegetables, or something high in protein, can curb hunger and keep your electrolytes balanced.

However, it’s important not to indulge in a large amount of food after fasting. While it’s tempting, it may make it harder to achieve your long-term weight-loss goals and leave you feeling fatigued and bloated. Instead, introduce small meals when returning to your normal eating habits. Common signs that you’re low on electrolytes during fasting include fatigue, dizziness, cramps and headaches.

Stay Busy, But Keep It Mild

Water fasting is challenging for the mind and body, but staying busy can help you take your mind off the hunger you may be feeling. For example, meditating can calm your mind so that you’re less focused on and consumed by physical sensations. Mild exercise is also great for keeping yourself busy, and can ward off fatigue.

Be careful about exercise: Amping up your training routine during a water fast can lead to adrenal fatigue, which can cause long-term damage to the body. Since a water fast can be stressful on your internal systems, it’s important that you’re not adding additional stress with high-intensity exercise. Light exercises like yoga, pilates, and walking are a great way to get your body moving in a low-impact way.

Water Fasting for Mental and Physical Health

Fasting is certainly a popular practice, but it isn’t something to be tried at random. Understanding why you’re fasting — and placing an intention behind it — is important for staying mindful when beginning a new eating pattern. Anyone who wants to start water fasting should have a clear understanding of both the benefits and risks.

By starting a new fasting routine mindfully, you can potentially boost immunity, lose weight, and increase resiliency against common health problems. As with any new dietary regimen, contacting a healthcare professional is the best way to be safe during the process. A medically supervised water fast has the potential to transform your life and give you greater insight into your long-term wellbeing.

Reading time: 4 min

Think of the perfect combinations in life. Peanut butter pairs well with jelly, burgers are nothing without fries, and even hot chocolate needs a few mini marshmallows to render the winter treat complete. Alone these items are just fine — everyone loves a plate of French fries, after all. But when combined with one another, suddenly they come alive in untold ways.

Just as we find ourselves looking for culinary combinations, researchers examining the foods we eat for health combinations. An area of research in which we’ve made progress concerns the class of drugs known as nootropics.

The word may sound intimidating, so let’s break it down: Nootropics are any drug, supplement, or substance that has the ability to improve cognitive function. Such improvements can relate to memory, creativity, motivation, intelligence, and beyond.

So which nootropics make for the perfect pair? Of the many nootropics that improve cognitive function and may complement one another, none are a better match than L-theanine and caffeine. Before we can discuss the benefits of caffeine and L-theanine, however, let’s look at their best qualities as individuals. Let’s start with the nootropic we know and love (and sometimes hate), caffeine.

Caffeine: America’s Favorite Nootropic

Most of us have a love-hate relationship with caffeine. Sure, we need it in our morning cup of Joe to jump start our day, but we hate admitting how dependent we are on its energetic powers. Caffeine is found in over 60 plants around the world. We can find it in tea plants, tea leaves, kola nuts, and cacao.

And while caffeine is found naturally in many places, it’s also produced synthetically and added to foods, medicines, and drinks. Though the amount of caffeine can vary greatly between substances, the average 8 oz cup of coffee contains 95-200 mg of caffeine.

So how exactly does caffeine work? In order to function as a cognitive stimulant, caffeine assumes an interesting role in our brain that keeps us going should we ever grow tired.

As neurons fire endlessly in our brain throughout the day, a neurochemical called adenosine will build up over time and reduce neuronal activity. This will cause us to feel sluggish, dull, and far less alert as the day progresses.

But caffeine comes to the rescue because it can mimic adenosine and prevent it from slowing down those important neurons. This is why we receive a boost of energy when we consume caffeine — it stops our brains from growing lethargic.

As any coffee drinker can testify, caffeine produces a number of side effects in the body that range from good to bad. It can stimulate the nervous system and make us alert, while also boosting working memory and even decreasing the odds of specific cancers.

Caffeine can increase our reaction time and improve cognitive performance. But it can also raise our blood pressure, increase our heart rate, produce those classic caffeine jitters, or lower sleep quality. The effects of caffeine are dependent on how much we consume and how often.

Should we choose to drink tea to get our caffeine instead of coffee, chances are we’ve already associated with caffeine’s perfect partner, L-theanine.

L-Theanine: The Amazing Amino Acid

L-theanine is an amino acid found primarily in specific plants. Of the plants we consume most often, we can find L-theanine in green tea, black tea, and certain mushrooms.

Taken to reduce anxiety and depression, L-theanine performs similar actions to gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter that blocks excitatory responses in the brain. L-theanine blocks these excitatory responses. As a result, it can lower blood pressure, decrease heart rate, and reduce stress hormone levels in the body.

A typical cup of brewed black tea will contain approximately 24 mg of L-theanine, while a typical cup of brewed green tea will contain 8 mg of L-theanine. The cup of tea we choose to consume will determine the effects of L-theanine, as certain teas contain more L-theanine than others.

As we’re winding down in the evening, L-theanine can also help us sleep by generating alpha brain waves that are associated with relaxing activities such as daydreaming and meditation. Yet oddly enough, it can also help us maintain focus when we begin our day. A systematic review found that subjects performed attention tasks better after supplementing with L-theanine.

L-Theanine and Caffeine: How They Work Together

Now that we’ve gained a basic understanding of both caffeine and L-theanine as individual nootropics, it’s time to discuss why these two make for the perfect combination.

Think, for a moment, of the many drawbacks related to caffeine. It causes stress, anxiety, restlessness, and even increases blood pressure. As the perfect partner, L-theanine works to correct these negative qualities, thus ensuring our caffeine intake experience is far more pleasant.

Because caffeine replaces adenosine in the brain, our minds are stimulated and running a bit too free. But when we add L-theanine to the conversation, that excitatory response is inhibited, and stress is managed as a result.

Additionally, L-theanine will eliminate caffeine’s ability to constrict blood vessels, so increased heart rate and blood pressure are no longer an issue. Clinical trials from a 2008 study conducted by Owen GN showed fewer headaches and less tiredness when subjects mixed the two nootropics, compared to consuming caffeine on its own. It’s as if we’re consuming caffeine without the negative side effects we often encounter.

But the combined effects of L-theanine and caffeine don’t simply stop at addressing physiological stress responses. Research conducted by Crystal Haskell and her colleagues at Northumbria University showed that a combination of L-theanine and caffeine improved reaction times for delayed word recognition.

Additionally, in a 2017 study, subjects reduced the amount of time it took to respond to flashing light cues on a computer, which suggested an improvement in acute attention.

Yet as with most combinations in life, not every aspect of the L-theanine and caffeine combination is entirely harmonious. While some studies have shown promising results, others have been unable to reproduce the same results under similar conditions.

For example, one study found there to be no significant increase in subject alertness at all. Others have postulated that L-theanine may even mitigate caffeine’s cognitive benefits.

There are also some important medical cautions worth noting. L-theanine should not be combined with blood pressure medications because L-theanine naturally reduces blood pressure.

Caffeine should not be taken with stimulant drugs because these work similarly to caffeine, and may fatigue our central nervous system when combined. Always consult a medical healthcare professional before starting supplements in any form.

We Make a Great Pair

While some research suggests a combination of L-theanine and caffeine produces no health benefits, most results have remained promising. For those looking to increase cognitive function or simply calm the caffeine jitters, combing these nootropics may be the answer.

Take some time to understand how these nootropics work within the body, consult the proper medical professionals, and reap the benefits that may follow. When the stimulating effects of caffeine are matched by the calming support of L-theanine, a productive and fruitful day is on the way.

Reading time: 6 min

When it comes to health, finding out that your numbers are not normal can be frightening. Whether it’s blood pressure or the number of quality hours of sleep you get, abnormal numbers can indicate a variety of health issues. But, once you know what’s making your numbers abnormal, you can take steps to remedy the problem.

You may be wondering what a normal blood oxygen level is. Most people don’t pay much attention to this metric, but it’s a key tool used by doctors to get a picture of your overall health. For people who suffer from sleep disorders, heart disease and breathing issues such as asthma, sleep apnea and chronic obstructive pulmonary disease (COPD), tracking oxygen saturation levels can help in managing treatment plans.

Here, we’ll show you what constitutes a normal blood oxygen level and highlight what happens if your levels are low. We’ll go over how to measure your blood oxygen saturation level, symptoms, causes, and what you can do if your numbers are not normal.

What Is a Normal Blood Oxygen Level

Blood oxygen saturation is a measure of how much oxygen is in your red blood cells. Within these red blood cells, iron attaches to oxygen atoms, transporting the oxygen to organs throughout the body. Oxygen is important to cellular health and low levels can cause symptoms ranging from dizziness to difficulty breathing.

Normal blood oxygen levels can vary from person to person, and factors like where you live can result in variations. Normal oxygen levels may be different for healthy individuals and those with chronic diseases.

People who live at high altitudes tend to have lower blood oxygen levels, which can be normal for that environment. That’s because there is less oxygen at high altitudes and less air pressure. People who live at sea level and travel to the mountains may experience a drop in blood oxygen saturation levels compared to their normal saturation levels. That’s because they are not used to the lower oxygen concentration in the air.

Finding your normal blood oxygen level takes some time. By testing your levels regularly, you’ll be able to see trends and if there are any dips in your baseline.

In general, there are three categories doctors use to determine whether your blood oxygen levels are normal. There are two different measurements depending on what type of test is used (more on that later). The basic guidelines are:

  • Normal: 75 to 100 millimeters of mercury (mm Hg) using an arterial blood gas test or 95% to 100% using a pulse oximeter.
  • Low: Less than 75 mm Hg or less than 95%.
  • High: High blood oxygen levels typically only occur if you’re using supplemental oxygen. If this occurs, a doctor will lower the amount of oxygen usage to get numbers back to a normal range.

Your normal numbers may be lower than these guidelines, particularly if you have a condition like COPD. Talk to a qualified healthcare professional to find out what is normal for you. If you suffer from an underlying health condition, a doctor can outline a normal range and help you identify when to take action if levels are too low.

How To Check Your Blood Oxygen Level

There are two main ways to measure your blood oxygen levels. The first test, known as an arterial blood gas test (ABG) can only be done by a doctor. The second test, a pulse oximetry test, can be done on your own at home. Here’s what to expect from each type of test.

Arterial Blood Gas Test

The ABG test measures for partial pressure of oxygen in the arteries, also known as PaO2. It tests for levels of oxygen as well as carbon dioxide and pH. These readings are conducted in measurements called millimeters of mercury, also known as mm Hg. During the ABG test, a doctor will draw a blood sample from an artery rather than a vein since arteries carry oxygen-rich blood cells. Doctors typically use the radial artery — located on your wrist — or the femoral artery, which is located in your groin. Results are usually ready within 15 minutes.

The ABG test can be uncomfortable and slightly painful. Because arteries are deeper than veins, larger needles are used to draw the blood. The pain is temporary and localized, and the benefit of this type of oxygen saturation test is that you’ll get a detailed analysis of your blood. You can also apply pressure to the injection site immediately following the blood draw to help reduce pain.

Pulse Oximetry

A pulse oximeter test is a non-invasive alternative to the ABG that can be done at home. A pulse oximeter is a small device that attaches to your fingertip, toe or earlobe. It uses infrared light to determine the oxygen levels in your red blood cells. You’ve probably seen this device before if you’ve ever visited a doctor’s office. Along with blood pressure cuffs, it’s a common tool nurses use to get a reading of your vital signs.

A pulse oximeter reading measures blood oxygen levels in percentages known as SpO2 or peripheral capillary oxygen saturation. The reading is a percentage that compares the amount of oxygen your blood is carrying to the maximum it can carry.

A pulse oximetry test is painless and easy, though it is slightly less accurate than the ABG test. To take the test, you’ll need a pulse oximeter device or a health tool like the Biostrap wearable. Both types of devices use infrared light to get a reading of your blood oxygen level. Blood that is rich with oxygen absorbs light differently than blood that doesn’t carry oxygen. This test reads those differences and gives you a percentage of your oxygen saturation levels.

All you do is put the wearable on your wrist or affix the pulse oximeter to your fingertip. Keep the pulse oximeter on until it gives you a reading. If you are using a pulse oximeter to test oxygen saturation during exercise, keep the device on until you are finished working out. When using a pulse oximeter, make sure to remove any dark-colored nail polish as it can interfere with the infrared light and result in incorrect readings.

Symptoms of Low Blood Oxygen Levels

Low blood oxygen levels result in a condition called hypoxemia. It’s basically a condition where your body isn’t getting the proper amount of oxygen to function at optimal capacity. When your organs aren’t getting enough oxygen, you may develop some of the following symptoms:

  • Chest pain
  • Shortness of breath or difficulty breathing
  • Wheezing
  • Confusion
  • Headache
  • Dizziness
  • Rapid heartbeat
  • Increased stress and anxiety
  • Irregular pulse rate
  • High blood pressure
  • Changes in vision
  • Cyanosis, a medical condition that causes the skin to turn bluish

Why Your Blood Oxygen Level May Be Abnormal

There are many reasons why your blood oxygen level may drop below your normal numbers. As mentioned, changing elevation can cause drops in blood oxygen levels, particularly if you live at lower altitudes. Underlying health conditions can cause levels to be lower than normal and taking certain medications may also decrease blood oxygen levels. Here are some of the main culprits behind low oxygen levels in the blood.

  • High altitude
  • Air pollution
  • Smoking
  • Heart disease
  • Lung conditions including COPD, asthma, and acute respiratory distress syndrome (ARDS)
  • Sleep apnea
  • Influenza and coronavirus infections like COVID-19 that cause pneumonia
  • Emphysema
  • Pulmonary fibrosis, a lung disease that causes scarring
  • Medications, particularly pain pills
  • Carbon monoxide poisoning
  • Anemia

What To Do If Your Blood Oxygen Level Isn’t Normal

The best treatment plans start by identifying what’s causing low oxygen levels. To do this, you’ll need to start by measuring your blood oxygen levels. Talk to a doctor and explain your medical history, whether you’re taking any medications, and any lifestyle changes that may be contributing to the problem.

If your levels are low due to elevation gain, this can be easily remedied by returning to lower elevations. If you’re susceptible to oxygen level changes due to altitude, you can also try acclimatizing — a process where you slowly increase elevation while allowing your body to adjust to the changes over time.

If you find yourself over 8,000 feet above sea level and have difficulty breathing, develop blue or grayish skin, and experience difficulty walking, visit a doctor. These are signs of high altitude sickness which can be life-threatening if untreated.

For most other cases, low blood oxygen levels are treated with oxygen therapy or supplemental oxygen. Depending on your oxygen needs, you may receive short-term treatment or something more long-term — particularly if you suffer from a lung disease. You can get oxygen at the hospital or your doctor’s office for short-term treatment. For long-term oxygen therapy, you’ll need to get a doctor’s prescription to take an oxygen tank home with you. Talk to a doctor to determine the right level of oxygen and how often you should be using it.

People with respiratory conditions can take medications to help keep the disease in check. If you have asthma, taking long-term asthma control medications can help reduce flare-ups and the asthma attacks that drop oxygen levels.

Lifestyle Changes To Improve Your Health

Low blood oxygen levels can indicate an underlying condition. Sometimes low levels are simply the result of the outside air quality, while other times they signal a more serious condition. Staying healthy is all about making healthy choices. To reduce the risk of developing low oxygen levels, exercise regularly and avoid smoking.

Monitoring your health is another great way to stay ahead of any issues. With the Biostrap health tracker, you can easily check your blood oxygen saturation levels, heart rate variability, and sleep patterns to ensure you get the rest you need to live a healthy life. The mobile app helps you track and monitor all your metrics, plus you’ll find workouts on everything from meditation to weight training to help you stay healthy and happy.

Reading time: 5 min

Binaural beats are a fascinating piece of technology that claims to reduce stress and anxiety while increasing your state of relaxation. These beats are created by combining different sound frequencies to produce a singular tone, and they’re popular on both music streaming applications and YouTube alike. Let’s take a closer look at one area impacted by binaural beats: sleep.

While it’s true that sound can influence our stress levels and even our cognitive performance, many questions remain about the efficacy of these slow-wave sounds. What do binaural beats actually do? Why should you use them during sleep? And can you really boost your brain health with a little help from isochronic tones?

Let’s drop the beat and break down this fascinating topic in greater detail to learn everything there is to know about binaural beats and how they can impact your sleep.

What Are Binaural Beats?

As sophisticated as they may sound, binaural beats are nothing more than two different frequencies playing at the same time. With one frequency in each ear, the brain perceives them as a singular tone. Promoted by psychologists, researchers, and healthcare professionals alike, many claim these beats can improve working memory and long-term memory, as well as strengthen connections within the many networks of the brain.

The theory behind such an idea goes something like this: When a different tone is played in each ear, your brain will perceive an entirely new tone that’s essentially the difference between the two separate tones you hear. Your brain is “tuning” itself into a new frequency.

To accomplish this task, you’ll need a pair of headphones. If you start to play a binaural beat that sends a 280-hertz tone into your left ear and a 300-hertz tone into your right ear, your brain will naturally process and absorb a 10-hertz tone. While you won’t be able to hear this tone (10 hertz is so low that you can’t actually hear it), your brain will still be affected by it and benefit from the inaudible auditory beat.

Why is this exposure to sound waves that we can’t hear so beneficial? Science suggests exposure to binaural beats can create changes in our brain’s state of arousal. Listening to different tones that create a singular low-frequency tone will trigger our brain to transition into a state of slow-wave activity — the perfect state for relaxation — lowering anxiety and making it easier to both fall asleep and stay asleep.

Different Types of Brain Waves

​To better understand how binaural beats interact with your brain, we need to take a brief detour to discuss brain waves and what they represent in terms of our emotions, mental activity, and state of consciousness.

Brain waves are created by a pulse of electricity that comes from neurons as they communicate with one another. When we think, experience emotion, or act on how we feel, we trigger neural communication. brain waves are influenced by how we feel and what we do in the world around us.

There are four primary types of brain wave frequencies that will be influenced by your emotions and your world. Binaural beats can influence these brain waves as well.

Beta-Frequency Waves

Beta-frequency brain waves are associated with elevated levels of alertness and arousal. When beta brain waves are dominant, we’re ready to focus, to make decisions, and to think analytically.

As you analyze an issue in the office or amongst friends, chances are high that you’re in a beta-dominant state. Beta waves are fast and have a higher frequency (between 15-40 hertz), and higher levels of beta-frequency waves are associated with anxiety.

Alpha-Frequency Waves

Alpha-frequency brain waves are associated with relaxation. As brain waves that are both slower and lower in frequency (between 9-14 hertz), alpha waves occur when you’re calm and collected, but still alert and aware of your surroundings.

Alpha waves are additionally associated with a meditative state and with your ability to be creative. Those who practice yoga have likely experienced this alpha state.

Theta-Frequency Waves

Theta-frequency brain wave patterns are associated primarily with deep relaxation and some stages of sleep, including lighter stages on non-REM (NREM) sleep. Because REM sleep is more wakeful, it’s mostly composed of beta-frequency waves and other activities that are associated with being alert and awake.

Deeper forms of meditation produce theta waves, which are slower and have a lower frequency (between 5-8 hertz) than Alpha waves. If you need a prime example of theta waves, simply think of that moment in bed when you’re drifting in and out of sleep. Everything is fuzzy, dreamlike, and difficult to remember. That’s when your theta waves are most active.

Delta-Frequency Waves

Delta waves are slow-wave, low-frequency brain waves (between 1.5-4 hertz) that can be found during deep sleep. These are found during the deepest stages of meditation and dreamless NREM sleep.

Binaural Beats and Brain Waves

After learning a bit more about the four brain wave frequencies, two things might become apparent. First, faster and higher-frequency brain waves are associated with states of arousal. These brain waves suggest you’re awake, alert, and prepared for whatever comes next. And second, lower frequency waves are associated with deeper states of relaxation or sleep.

Truth be told, we’ve known for decades that different sound waves can produce or encourage different brain wave patterns. We refer to our brain’s process of aligning with certain frequencies as entrainment.

The process of brain wave entrainment suggests that we can, in fact, be influenced by the effects of binaural beats. By exposing our brain to low-frequency tones, we can encourage the brain’s output of alpha, theta, and delta-frequency brain waves that lead to a state of relaxation or healthy sleep.

How Binaural Beats Can Improve Sleep

Brain wave activity during your sleep state is different from brain wave activity when you’re awake. But as it turns out, lowering brain wave frequencies through binaural beats can also compel your body to alter three hormones that are associated with sleep and well-being: DHEA, cortisol, and melatonin.

DHEA is a master hormone of sorts that helps the body produce other hormones as needed. When we sleep, DHEA suppresses cortisol — the hormone that stimulates alertness and provokes stress when released by our body at elevated levels. By utilizing binaural beats, we can actually increase DHEA levels, which will in turn regulate other hormones that could otherwise keep us awake.

Cortisol, on the other hand, tends to rise and fall with our circadian rhythm. These levels rise in the morning when we wake and fall at night as we sleep. If our cortisol levels are too high at night, it can render us unable to sleep — at which point, we may experience insomnia. Binaural beats have the ability to lower cortisol levels just in time for us to drift off to sleep.

Finally, melatonin is the hormone known for promoting and regulating sleep. Melatonin levels will rise dramatically in the evening as our body and mind wind down. Binaural beats can help our body increase melatonin levels to ensure we receive a full night of high-quality sleep. We can even use supplements of melatonin or magnesium to fully ensure our body is ready to get the sleep it needs.

As we can see, binaural beats are capable of more than simply lowering brain wave frequencies. They can help boost our sleep-promoting hormones as well.

Risk Factors Associated With Binaural Beats

By and large, binaural beats are a safe and noninvasive method for helping us fall asleep. That being said, there are a couple of risk factors associated with binaural beats that you should be aware of.

For instance, those who are prone to epileptic seizures should refrain from using binaural beats as the frequencies may trigger abnormal neurological impulses that cause epileptic seizures. Additionally, binaural beats can affect heart rhythms, so those who have a pacemaker or other cardiac issue should speak with a doctor before using binaural beats for sleep or relaxation.

If binaural beats aren’t for you, consider using sleep music or a white noise machine to fall asleep. These options still promote a calm and relaxing atmosphere in a noninvasive manner.

Get Some Sleep With Binaural Beats

From sleep medications to sleep therapy and beyond, there are many tactics we can use to help us get some shuteye. As a noninvasive and inexpensive approach to falling asleep, binaural beats have the ability to help many of us get the sleep our body craves.

If you’re considering using binaural beats, speak with your healthcare provider to ensure this approach is right for you. From there, all you need is a pair of headphones to help you get the sleep you need.

Reading time: 4 min

Alpha-GPC, or Alpha-glycerophosphocholine, is a natural compound found in your brain that serves a wide variety of functions. From improving memory and learning to enhancing overall cognitive function, Alpha-GPC is available in some countries as a medication and in others, including the United States, as a dietary supplement.

Yet many of us still don’t know exactly what Alpha-GPC is or even what it does. Let’s take a closer look at this nootropic to answer these very questions. We’ll determine what it is, how it can boost brain function, and what side effects it may cause along the way.

What Is Alpha-GPC?

Before we can discuss the specifics of Alpha-GPC, we must first take a closer look at two important nutrients in the brain known as choline and acetylcholine.

When we consume certain foods such as poultry, fish, eggs, spinach, and beets, our body absorbs a wide variety of nutrients that benefit us in various ways. One of these nutrients is known as choline, and though our body produces its own choline in the liver, our primary source of choline comes from our diet. Choline supports cell membranes as well as cell messaging, and it maintains our nervous system by producing the neurotransmitter acetylcholine.

Acetylcholine is an important neurotransmitter that sends signals to neurons, muscle cells, and gland cells in our body. Most notably, acetylcholine also plays an important role in the brain’s ability to function properly and recall information.

So, how do these compounds tie into Alpha-GPC? Well, when we consume Alpha-GPC in supplemental, dietary, or medicinal form, we’re also consuming large amounts of choline. This is because upwards of 40% of Alpha-GPC is made of choline. And once we’ve consumed Alpha-GPC, our body can use the choline it contains to support our brain and produce more acetylcholine.

Another compound that’s similar in nature to Alpha-GPC is called CDP-choline, or citicoline. Alpha-GPC and citicoline are often compared because they work similarly when consumed as supplements, but Alpha-GPC raises choline levels in the blood more than citicoline does. Because Alpha-GPC can be more readily used by the body to produce choline, it can provide more benefits. Let’s take a closer look at what those benefits may be.

The Many Uses of Alpha-GPC

Alpha-GPC has been used to treat a variety of brain-related conditions that lead to cognitive impairment. Some research suggests it may effectively improve brain health and physical performance as well. Now, let’s break down the uses of Alpha-GPC in greater detail.

Alzheimer’s Disease

Research suggests Alpha-GPC may be used to improve thinking skills in individuals who suffer from Alzheimer’s Disease, and the results from clinical trials have been promising. In a 2003 clinical trial of 260 patients suffering from Alzheimer’s Disease, the use of Alpha-GPC improved symptoms in every single trial participant. A separate 2014 Alzheimer’s study that examined 113 individuals found that Alpha-GPC boosted the effects of standard treatment.

Though we don’t fully understand how this process works, Alpha-GPC may prevent and even reverse cognitive decline in those suffering from Alzheimer’s, poor brain circulation, and other stressors.

Dementia

Dementia is not a specific disease, but rather “the loss of cognitive functioning — thinking, remembering, and reasoning — and behavioral abilities to such an extent that it interferes with a person’s daily life and activities,” according to the National Institute on Aging.

Alpha-GPC is available as an oral supplement or a shot in Europe, where 1,000 milligrams is administered to improve symptoms of dementia including behavior, mood, and thinking skills. Unfortunately, this form of Alpha-GPC is not available in the U.S.

Stroke Recovery

A stroke is an interruption of the blood supply to the brain. If left untreated, a stroke can cause permanent brain damage that may lead to cognitive defects. A 2001 study that reviewed three clinical trials of 2,500 stroke survivors found that Alpha-GPC can help recover mental functions after a stroke has occurred. Cognition improved in 70% of the stroke cases that were reviewed.

Unfortunately, these studies did not use control groups, so we can’t say with certainty that improvements would only be seen in stroke survivors. More clinical testing is needed to determine if Alpha-GPC truly plays a role in stroke recovery.

Athletic Performance

Alpha-GPC has gained popularity among athletes, weightlifters, and bodybuilders due to its reported performance-enhancing properties.

In two studies that monitored the athletic performances of 61 young men, Alpha-GPC improved speed, power, and pull force, with stronger effects on the lower body. A separate 2015 study that examined 22 individuals found that Alpha-GPC enhanced vertical jump power by 8.5%.

Research published in the Journal of the International Society of Sports Nutrition found that pre-workout supplementation with Alpha-GPC led to a spike in growth hormone secretion. It also led to a 14% higher bench press force, though it didn’t have any impact on power or recovery.

And finally, a 2012 study found that Alpha-GPC boosted growth hormone production and fat burning. Its effects on growth hormone were temporary and more pronounced in the elderly.

From this research, we’ve found that Alpha-GPC has the ability to improve athletic performance in healthy, young individuals by increasing power output during strength training or competitive pursuits. It may also stimulate muscle growth by increasing growth hormone, but evidence in this regard is more limited and the effects may be temporary.

Other Potential Uses

Aside from the uses listed above, Alpha-GPC may also improve memory, thinking skills, learning, and other mental conditions. Research that examines the effects of Alpha-GPC on our brain’s cognitive function is ongoing.

Side Effects and Risks

Side effects and risks associated with the consumption of Alpha-GPC remain minimal and non-life threatening. The most adverse effects in clinical trials include heartburn, headache, nausea, dizziness, skin rashes, and confusion.

The appropriate dose of Alpha-GPC will depend on several factors, such as age, weight, health conditions, and more. Though acute supplementation may seem harmless, experts believe that more testing is needed to determine an appropriate range of doses.

Alpha-GPC is a dietary supplement in the United States, and therefore, not regulated by the Food and Drug Administration (FDA). It’s best to seek medical advice from a healthcare professional before consuming Alpha-GPC in any form.

Things to Consider When Supplementing With Alpha-GPC

Some Alpha-GPC supplements are derived from soybean plants. While we all stand to benefit from reading product labels before consuming a dietary supplement, those that have a soy allergy should pay extra attention when searching for the right Alpha-GPC product.

Additionally, Alpha-GPC absorbs moisture and breaks down over time, so any Alpha-GPC supplement should be stored according to package instructions.

Is Alpha-GPC Right for You?

Alpha-GPC is a remarkable compound with a wide assortment of potential uses. From improving cognitive brain function to boosting physical performance, research suggests Alpha-GPC may aid our lives in more ways than one.

Keep in mind that research is ongoing and more testing is required to determine the proper dosage guidelines and potential uses. Speak with your healthcare provider to determine if Alpha-GPC is right for you.

Reading time: 4 min

“The subject of athletics has not been understood until recently; nor has the best method of training been investigated,” Dr. Sargent told a Harvard audience on March 6, 1896. Dr. Sargent seems to be suggesting that everything about athletic training was now settled. 121 years later, however, there is still so much to learn about our amazing bodies, and how to maximize what they can do.

One useful measure is resting heart rate (RHR). A low RHR (along with optimal SpO2) is the hallmark of cardio health. RHR is just what it sounds like, the measure of how many times your heart beats (per minute) when you are at rest. (as opposed to heart rate variability (HRV), which measures the variation between beats.)

You can measure it with wearable technology or kick it old school (2 fingers at the neck) Either way, knowing your baseline RHR will help you monitor progress, and identify problems, before other symptoms emerge.

A normal resting heart rate for adults ranges from 60 to 90. When it comes to RHR, it important to know how to lower resting heart rate. Elite athletes have RHR in the 50s, 40s, even 30s. High RHR is associated with an increase in risk of death. But can you change your RHR? If so, how? And by how much?

How Can You Change Your Resting Heart Rate?

The good news? Yes, you can lower your resting heart rate.

The 3 best ways to reduce your RHR?

  • Exercise
  • Relaxation
  • Sleep

(Need help remembering? Picture yourself riding a bike. (exercise) Your stress melts away. (relaxation) You’re so stress-free you fall into a deep slumber. (sleep.)

Exercise

“It is very possible and even common to lower your resting heart rate through exercise,” says Tyler Spraul, a Certified Strength and Conditioning Specialist and Head Trainer at Exercise.com. “The type of exercise is not important, as long as you are challenging your cardiovascular system with your workouts.”

The 4 most Important types of exercise for health include strengthening, stretching, balance, and aerobic exercises. And exercise doesn’t just lower your RHR. Harvard Medical School reminds us that exercise will also ward off depression, enhance your sex life, sharpen your wits, and improve your sleep.

As you train your cardiovascular system,” Spraul explains, “you will increase its efficiency and capacity. What ends up happening is that your heart is able to do more work with less effort (pump more blood throughout your system while requiring less energy and exertion to do so), so your resting heart rate goes down.“

It’s important to find activities you like, and to mix it up, to avoid boredom and make sure you’re working all parts of your body. Interval training (alternating intensive workouts with periods of rest) is an especially effective way to lower your RHR.

Sleep

Sleep is emerging as a new frontier of health, with implications for cardio health, cognition, mood and even mortality. That’s right, a good night’s sleep over time can forestall death.

Disturbed sleep negatively impacts heart health and can increase RHR. Sleep has been shown to promote cardiac health and mood, which in turn has a protective function across all aspects of your health and performance. Sleep also protects against weight gain, which can increase your RHR.

Relax!

Whether we are resting, or stoked with adrenaline during a ‘fight or flight response’, our hearts are in play.

Reduce stress, and your RHR will naturally fall. Increase stress? And it will rise, regardless of sleep and exercise. Stress in teens (measured by parental corporal punishment) was found to increase adolescent resting heart rate variability, while positive parenting helped improve RHR and HRV.

Yet reducing stress is easier said than done.

Some stress is beyond our control. But that makes it even more important to control what we can, and incorporate stress reduction as a daily component of our healthy lifestyle.

These interventions are widely successful to reduce stress.

  • Breathing exercises
  • Exercise (there’s that word again)
  • Higher physical fitness was found to have a protective effect against training distress in collegiate soccer players.
  • Meditation
  • Yoga.
  • A recent study of yoga and children showed yoga practices of even short duration (3 months) can “reduce anxiety status and decreases resting heart rate” by affecting the autonomic nervous system.
  • Nutrition (avoid sugar, caffeine and alcohol)
  • Relaxation Apps

How Quickly and by How Much?

A recent poster on Researchgate asked, “Is it possible to decrease the heart rate by 20 bpm in 6 months” The consensus? Yes, through exercise, but you need to be healthy to start, and work super hard.

G. Filligoi of Sapienza University of Rome recommends the relaxation route: “You can decrease heart rate by respiration exercises, yoga, meditation. I would suggest some self-consciousness approach in order to reduce the anxiety, nervous stress, and similars.

Not everyone agrees it’s possible. “In my opinion,” says Oscar Fabregat-Andrés of MED Hospitales, “it is not possible to modulate baseline heart rate in such magnitude, because although exercise is able to regulate autonomic system, “vagal tone” necessary to reach this rate is not performed in 6 months.”

Does Lowering your RHR Make you Healthy?

If a low RHR is a sign of health, does that mean lowering your RHR automatically makes you healthy? No, but it’s evidence you’re on the right track. Measuring RHR is a safe, non-intrusive way to track the success of your fitness regime, and spot trouble early.

“A low resting heart rate doesn’t necessarily lead to better health in and of itself,” says Spraul, “but it can be used more as an indicator of the effectiveness of your training methods.”

This effectiveness can be positive, or not. “If you are doing workouts that challenge your cardiovascular system and your resting heart rate decreases over time,” he says, “that is a good sign that you are doing the right things.” But it’s important to measure it regularly, even, especially, if you are training hard. An unexpectedly elevated RHR can be a sign of overtraining. “Sometimes the resting heart rate can actually increase,” Spraul cautions, “which is a sign that you have over-stressed your body’s systems and may need to focus on better recovery or

Back to the Basics

Back in 1896, Dr. Sargent wasn’t so far off the mark. “The modern idea of training,” he told his Harvard audience, “is to seek things “which will contribute to health and strength: diet, sleep, bathing, proper clothing and exercise.” “Exercise with energy,” he concluded, “to stimulate the heart and lungs and increase respiration and circulation.” Some things never change.

Exercise stimulates the heart, in a good way. And RHR is a key measure of how well it works.

Reading time: 5 min

What do drinking chilled water, taking a cold shower, and polar bear plunges all have in common? They’re all examples of cold thermogenesis, or therapeutic cold exposure.

Immersing in freezing water may be uncomfortable, but exposing yourself to cold temperatures can boost metabolism and ward off disease. Cold exposure is also important for regulating body fat levels and can help promote healthy weight management.

In the same way that we get goosebumps or start to shiver when we’re chilly, thermogenesis is another bodily response to cold. Since it’s internal, however, many people don’t know the ways it benefits the body beyond keeping it warm. Here’s how cold thermogenesis works, plus what it can do for your long-term health.

What Is Cold Thermogenesis?

Thermogenesis is a way we produce heat to keep our bodies warm. Cold thermogenesis kicks this process into overdrive. When you’re exposed to colder environments, your body works harder to maintain homeostasis and regulate core temperature. It produces more energy to stay warm, burning calories to produce that heat. This in turn stimulates metabolism. Hormones involved in body temperature regulation also play a role in stimulating heat-related fat breakdown, including epinephrine, norepinephrine, and thyroid hormones.

White and Brown Fat

Cold thermogenesis influences metabolism because it stimulates brown adipose tissue (BAT), also known as brown fat. Adiponectin, or brown fat gets its color from high levels of iron.

The other type of fat in the body is white fat — the fat type people are most commonly familiar with. White fat helps insulate the organs, but too much can be unhealthy.

The body looks to brown fat to stay warm because it provides body heat without causing shivering. The side effect of this heat production is that it helps the body burn fat to promote fat loss. It also lowers the heart rate, burns calories, and promotes weight loss. The fat-burning power of brown fat makes it a potential treatment for obesity and metabolic diseases.

Benefits of Cold Thermogenesis

 

Cold exposure, also known as cryotherapy, is the act of intentionally exposing oneself to cold environments to promote health. In addition to stimulating metabolism and burning white fat, there are many cold thermogenesis health benefits.

Both short-term and long-term benefits abound. Cold thermogenesis benefits often become evident immediately after intentional cold exposure, and people tend to feel happier and more energized after immersion in cold water.

Here’s an overview of how cold thermogenesis benefits the mind and body in the long term.

Brain Health

The breakdown of brain synapses, or degeneration, is a normal side effect of aging. It causes cognitive decline, memory loss, and diseases like Alzheimer’s and Parkinson’s. However, exposure to cold stimulates cold shock proteins, which in turn decrease degeneration. Dr. Rhonda Patrick describes cold thermogenesis as “the link between synapse regeneration,” and says, “cold exposure and cold shock proteins may pose as significant puzzle pieces into combatting cellular degeneration and aging.”

Immunity

Exposing yourself to cold environments (like ice baths) on a regular basis may also boost immunity. Patrick explains that the cold increases white blood cell count as well as cytotoxic T lymphocytes, which help combat cancer cells.

Cold thermogenesis also boosts immune function by decreasing inflammation and allowing the body to heal more quickly. The immunity-boosting effects of cold thermogenesis can also be tied to its ability to stimulate norepinephrine release. This causes “an increase in natural killer cell count and activity, and a rise in circulating levels of interleukin 6, all of which can massively improve your immune system integrity,” according to Julie Shanebrook.

Sleep

Cold therapy has also been shown to improve sleep, ability to fall asleep, and depth and quality of sleep. One study found that just three minutes of whole body cryotherapy improves objective and subjective sleep quality in healthy active people. This could be due to the fact that pain relief and parasympathetic nervous system activity increased during slow wave sleep (SWS).

Resiliency and Recovery

 

More athletes are turning to cold thermogenesis to promote recovery and reduce workout-related fatigue. This is because total body cold immersion results in the nervous system creating vasoconstriction, which narrows the arteries and blood vessels. This reduces blood flow to damaged muscles, in turn reducing inflammation and mitigating the onset of swelling and bruising.

“Whole-body cryotherapy offers a technological and scientific approach to addressing fatigue, delayed muscle recovery, as well as pain and inflammation caused by rigorous training and exercise,” says Willie Mueller at Cryozone.

Cryotherapy Methods

Not everyone will benefit from cryotherapy, so it’s important to talk to your doctor before starting it. Cold showers and ice baths are some of the most common ways to stimulate cold thermogenesis. Dipping a body part, such as your head, into cold water can also spark metabolism if you’re not ready to immerse your whole body. Cold baths have been shown to offer more benefits after endurance training rather than strength training, but more research is needed.

Sleeping in a cold room is another way to induce cold thermogenesis, and it may be easier than dunking in an ice bath. One study showed that a month of exposure to cold temperatures during sleep increased brown fat in healthy men. It also improved insulin sensitivity, suggesting that a cold environment may support people with impaired glucose metabolism or pre-diabetes.

Ice Baths and the Wim Hof Method

 

Neurosurgeon and paleo expert Jack Kruse offers a few tips for starting a cold thermogenesis routine at home. Before starting, he suggests drinking 16-32 ounces of water and eating a high-fat or high-protein meal. Next get a bucket of water that’s 50-55 degrees and dunk your face in, holding for as long as you can. He says to continue for a few weeks until you can hold for longer.

Another method is to take an ice bath in cold water with 20lbs of ice on your chest. Wear socks, gloves, a t-shirt and a hat to keep the body warm until it adjusts. Then you can take the outer protection off. Stay for 45 minutes. In both instances, it’s important that you don’t allow your skin temperature to fall below 50-55 degrees.

These methods follow the Wim Hof method, as Dave Asprey of Upgrade explains. The Wim Hof method works to stimulate the vagus nerve, which is connected to the rest of the nervous system. In turn, exposing even just your face to cold water can give you these benefits while increasing tolerance to cold environments.

Additional Wim Hof research has shown cryotherapy to improve concentration, willpower, and sleep while reducing depression and autoimmune symptoms. These benefits can play a vital role in a person’s mental health. “The method helps you to increase mental resilience, which allows you to better deal with daily stressors. It also increase your focus, concentration and willpower, which are all very important factors for good mental health,” says Wim Hof.

Cold Thermogenesis and Long-Term Health

Cold thermogenesis is a popular health trend aimed at supporting long-term wellbeing through exposure to cold. Immersing either the whole body or certain body parts in cold environments stimulates the burning of white fat, the increase of brown fat, and a boost in metabolism.

Cryotherapy methods have also been shown to improve muscle recovery, boost immunity, and improve brain health. Cold thermogenesis can help you understand sleep and recovery, and have a lasting impact on your ability to lead a happy, disease-free life.

Reading time: 5 min

We know we need water, but there remains confusion as to whether or not we should drink water before we go to sleep. Some assume that drinking water just before bed will keep us hydrated throughout the night while others question whether it has any real health benefits. Which is true, and what’s nothing more than “watered-down” information? We set out to answer this question.

The Cons of Drinking Water Before Bed

Drinking water before bed can influence your body in both negative and positive ways. Below, we’ve broken down the primary means by which drinking water before bed can negatively impact your body.

Your Sleep Cycle

Your body’s sleep cycle is a complex process that dictates when you feel sleepy, when you feel alert, and how often you wake throughout the night. Interrupt this cycle and you may experience sleep deprivation symptoms such as sleep inertia, afternoon grogginess, or a change in your mood.

While drinking a glass of water before bed may provide your body with fluids, it can also impact your sleep cycle by increasing overnight urination, also known as nocturia. Because your body requires six to eight hours of sleep each night, fluid intake can influence how often you wake to use the bathroom.

This is why sleep deprivation can then take hold. Research indicates a lack of sleep can negatively impact your immune system, your energy levels, and more.

This information shouldn’t dissuade you from drinking water before going to sleep. As you’ll soon find out, there are some health benefits to nightly hydration. But it should serve as a cautionary note — if you decide to drink water before bed, be sure the amount of water you consume will not impact your sleep. Your body needs both water and sleep to function properly.

The Benefits of Drinking Water Before Bed

 

While drinking water before bed can interrupt your sleep cycle or create nocturia, it can also provide numerous benefits. We broke these down in greater detail below.

Detoxing Your Body

Water acts as a natural cleanser that helps your body rid itself of unwanted toxins while simultaneously aiding your digestive system.

Should you choose to drink water before bed, consider drinking warm water or hot water. Warm water increases blood circulation and your sweat output. Though sweating during the night may cause your body to lose fluids, it will also remove excess salts and cleanse your skin cells, thus acting as a natural detox for your body.

Preventing Hangovers

​Ah yes, the dreaded hangover. You spent the night celebrating with friends and woke the following morning feeling as if you were just hit by a truck. When you drink alcohol, you will need to urinate more, further promoting dehydration and amplifying the symptoms of a hangover.

The best way to avoid the classic hangover is to drink alcohol in moderation — this much we know. But water can help reduce a hangover’s effects. These include drinking water between each alcoholic beverage and drinking a couple of glasses of water before going to bed.

If you anticipate spending the night out with friends, leave a full water bottle on your bedside table before heading out for the night. When you return, drink a few ounces of water to avoid a serious headache the next day.

Improved Mood and Mental Performance

Do you ever feel better when you’re fully hydrated? Maybe your mind feels sharp or instead you’re simply on your game. Believe it or not, a lack of water can negatively impact your mood and disrupt your sleep cycle in-turn.

Research suggests that those who are consistently hydrated feel better than those who are not. By drinking enough water during the day and before bed, you stand to replenish fluids and get better sleep that will boost your mood and mental strength.

Weight Loss

No, it’s not some fad from the back of a tabloid magazine. Believe it or not, drinking cold water before bed actually burns calories simply because your body needs to warm up the water. It works twice as hard to do so while you’re asleep, as your body is in a state of rest with little movement.

Don’t expect this tactic to burn calories at a similar rate to exercise. But cold water intake can still burn calories while you sleep, and capitalizing on this is as simple as downing a glass of cold water before bed. However, the healthiest and simplest weight loss management relates to diet and physical activity.

Drinking Lemon Water

Not only does drinking cold water at night benefit you, warm lemon water will do so as well.

Lemons are full of health benefits. While we often consume lemons because of their vitamin C content, they also contain other nutrients and minerals such as pectin, vitamin E, vitamin B. A glass of lemon water in the morning will boost your immune system and promote your well-being by eliminating free radicals that may otherwise promote illness and disease. Hot lemon water can also balance your body’s pH levels to promote cell function and structure.

But the benefits of drinking lemon water don’t end there. Lemon water also acts as a diuretic that increases urination to help purify your body and your urinary tract (again, moderate your bedtime consumption wisely). The citric acid in lemons can help prevent kidney stones by making your urine less acidic. And when you drink lemon water, it even keeps your breath fresh. (However, the citric acid can erode tooth enamel over time, so be sure to keep an eye on this.)

Moderate lemon juice and hot water before bed can promote a healthy lifestyle. It’s a natural remedy to maintain good health with very few side effects.

To prepare a cup of lemon water, squeeze fresh lemon or pour lemon juice into a mug of warm water. It’s a sort of healthy and rejuvenating lemon tea.

When Should You Drink Water?

Now that we’ve come to understand the many benefits of drinking water before bed, let’s discuss when you should drink water and when you shouldn’t.

Drinking water before bed has a number of benefits, but drinking too close to bedtime can disrupt your sleep cycle and impact your overall health. Over time, this can lead to issues such as heart disease and weight gain.

At the end of the day, you simply need to drink enough water to avoid dehydration while simultaneously ensuring you’re not waking in the middle of the night to use the bathroom. A general rule of thumb suggests you avoid drinking water two hours before sleeping to avoid waking up at night.

Most online guides will suggest drinking eight cups of water per day on average, though this may vary depending on your needs. For instance, you may need to consume more water if you’re physically active or if it’s hot outside. Drink water with every meal and when you’re hungry, and consume foods like fruits or vegetables that possess higher water content levels.

If you’re not sure how much water you should drink or when you should drink it, simply speak with a dietitian.

An Ode to Water

Our bodies constantly crave water in the hopes of replenishing fluids that are lost over time. From sweating to sleeping to bowel movements, our body is losing water that we need to replace. While drinking water before bed may influence your sleep cycle, it can also provide a number of health benefits you may want to consider taking advantage of.

Take time to determine how much water you should drink before bed. It should be enough to hydrate you without waking you to use the bathroom consistently. Otherwise, enjoy the many benefits of your body’s favorite fluid.

Reading time: 5 min

Our hearts thump steadily inside our chest ensuring we live to fight another day. How fast it beats when we sit still is called our resting heart rate (RHR). It’s a standard medical vital sign and a key measurement of health and fitness.

A quick Google search for normal resting heart rate will tell you: “A normal resting heart rate for adults ranges from 60 to 100 beats a minute.” But what if what we thought we knew was wrong? A quiet revolution has been taking place, and the internet is now just beginning to notice.

We take a deep dive into what makes a good Resting Heart Rate?

What’s normal?

The classic guideline for normal ranges between 60 and 100 beats per minute. The lower the better.

But it turns out that there is an immense difference between 60 and 100 beats per minute (BPM). 60 signifies health and vitality.  100 does not. Researchers now know: every increase in resting heart rate brings a heightened risk of illness and death.

The New Normal?

Back in 1992 prominent cardiology researcher David H. Spodick challenged the 60 to 100 guideline, suggesting a re-calibrated range of  50 to 90 BPM. The conventional limits were “established by consensus and never formally examined,” he said. Clinical experience led him to conclude that both figures were too high. So Spodick delved deeper: “We investigated this formally. The normal resting daytime heart rate ranges for sinus rhythm should be readjusted from 60-100 to 50-90.”

“About 50-70 beats per minute is ideal,” per WebMD, quoting cardiologist Suzanne Steinbaum, MD.

Yet 35 years later the 60 to 100 guideline persists. Even the American Heart Association (quoting the NIH) and Mayo Clinic cite 60 to 100.

Why Does it Matter?

It’s not just the high end of the range that spells trouble. New research shows every ten point increase in RHR increases your risk of illness and death, from all causes not just cardiac disease.

Ulrik Wisloff, co-author of one of the studies, explains, “The short answer is having an RHR above 85 may be very unhealthy. Keeping your resting heart rate below 70 is best.”

Mounting Research

Study after study confirms this.

A RHR of 100 can predict lowered mortality, even in healthy adults. The Canadian Journal of Cardiology reports, “elevated heart rate (90 beats/min or greater) is a risk factor, particularly for sudden cardiac death.”

In fact, a resting heart rate of more than 80 beats a minute brings a 45 percent greater risk of death from any cause. Even those with a relatively healthy RHR between 60 to 80 have an increased mortality risk (21 percent) over those with a rate below 60.

It’s not just heart trouble. A 28 year longitudinal study of 53,322 people in Texas found “a resting heart rate greater than 80 beats per minute is a strong predictor for future heart attacks, diabetes and even cancer.”

A meta review of 18 epidemiological studies showed “a mortality excess of 30% to 50% for every 20 beats/min increase” in RHR.

Cause or Effect?

Increasing evidence suggests that an elevated heart rate doesn’t just predict a higher risk. It may actually be causing it. Elevated heart rates can reduce the elasticity of the larger arteries. A high heart rate itself may be a cardiovascular risk factor. Researchers are now studying whether lowering the heart rate can reduce cardiovascular risk.

More than 32 studies prove elevated heart rate is an independent risk factor, suggesting that

lowering RHR may play a key role in the prevention of cardiovascular diseases.

It’s not just humans: “Across a wide range of mammals slower heart rates are associated with greater longevity

Even a RHR of 76 beats per minute, well within the classic 60 to 100 BPM guidelines, may be linked to a higher risk of heart attack.

A resting heart rate of more than 80 beats a minute brings a 45 percent greater risk of death from any cause. Even those with a relatively healthy RHR between 60 to 80 had an increased mortality risk (21 percent) over those with a rate below 60.

An elevated RHR is also linked to reduce ability to perform everyday tasks in the elderly. Researchers emphasize the need for early intervention: “Because functional disability develops gradually, it is important to identify it early and take steps to delay decline, such as exercise, medication and other interventions.” Senior in this study with the highest RHR had an  “80 percent increased risk of decline in their ability to do basic daily activities, and a 35 percent increased risk of decline in their ability to do more complicated daily tasks”.

Given this research, the widely quoted parameters of 60 – 100 are just plain wrong. The paradigm has shifted from “60 to 100 is normal” to “Keep your RHR as low as possible and see a doctor if it increases > 10 points”.

Elite Athletes and Resting Heart Rate

Like any muscle, the heart grows stronger with use. The stronger it becomes the more efficient it is. It can pump larger volumes of blood with less effort,Elite athletes and the tremendously fit have RHR far below 60. This signifies extreme efficiency of their cardiovascular system. Even for those of us who may not be ultra-fit, there are interventions to lower our RHR.

What Factors Affect Resting Heart Rate?

Internal

  • Emotions (increase)
  • Fitness (decrease)
  • Activity (increases)
  • Body size (increases)
  • Dehydration (increases)

External

  • Temperature (heat/humidity increase RHR)
  • Position (increases initially when you stand up, then stabilizes)
  • Medication (varies: beta blockers slow RHR, thyroid medicine can increase it)

How Can You Lower your Resting Heart Rate?

While researchers are still weighing the exact connection between an elevated RHR and poor health, it’s clear that a low resting heart rate is a desirable sign of fitness. The best way to lower your RHR is to become more fit. Exercise s the number one fix, especially aerobic movement that taxes and strengthens your heart.

Lose weight. Stop smoking. Eat healthy. Nearly every known factor to improve health will also lower your resting heart rate.

How Often Should You Measure It?

Harvard recommends that you “check your resting heart rate early and often”.

Everyone’s heart beats but not everyone’s heart beats the same way or at the same rate.

The standard measure of heart rate is beats per minute (how many times does it go thump thump thump over 60 seconds). The spacing between each beat is not uniform – that’s called heart rate variability, and it’s actually better to have MORE variability than less.  That shows your heart is capable of adjusting to changing stimuli inside and outside your body.

Our heart beats is that it varies wildly over the course of the day depending on whether we are still, active, calm, agitated or asleep.

So when it comes to measuring our heart rate, for purposes of accuracy and uniformity we measure it when we are at rest. We’ve been sitting still for a few minutes.

A study in the Journal of the American Medical Association says to follow your RHR over time. “A healthy adult is expected to have RHR of 70,” says researcher Ulrik Wisloff, PhD. If your HRH increases more than 10 beats, says Wisloff, get a thorough check of your heart and blood vessels and ask your family doctor for advice about lifestyle changes.

Digital health solutions, like Biostrap, now allow us to keep track of changes in our RHR. Given the research-driven paradigm shift, it’s not a moment too soon.

Reading time: 5 min

Memory loss has long been accepted as a normal part of aging. But what if we could slow the progression of cognitive decline through lifestyle factors like diet and exercise?

A growing body of research suggests that what we eat and how often we move play a major role not only in mental acuity, but in slowing the progression of Alzheimer’s, dementia, and other age-related brain disorders. Taking brain health into your own hands may boost your mental acuity while helping you live better for longer. Here’s a look at the promising research showing what it takes to stay sharp.

What Is Mental Acuity?

Mental acuity comprises a person’s ability to reason, focus, and recall information at optimum speeds. Losing mental acuity, or sharpness of the mind, is often referred to as cognitive decline — the key mental change associated with Alzheimer’s, dementia, Parkinson’s, and other brain and age-related disorders.

The reason why sharpness of the mind is so important is because it determines our ability to move through the world safely and effectively. When we can remember what we’re doing and stay present in the moment, we’re more equipped to get our needs met without encountering conflict.

Mild Cognitive Impairment

Cognitive decline can still occur even without the presence of a disease like Alzheimers. This is often referred to as mild cognitive impairment (MCI). While there’s no single cause, the risk for mild cognitive impairment increases after a stroke or traumatic brain injury. It can also occur as a side effect to certain medications, or in association with depression, anxiety, or sleep deprivation.

Signs that you’re experiencing MCI include struggles with remembering, planning, or following instructions. This decline in mental acuity may also make it harder to make important decisions. Since it can be hard to know when your memory is declining, many people rely on family and friends to explain changes in memory to both the patient and their doctor.

More patients with mild cognitive impairment go on to develop Alzheimer’s than those without it. “About 8 of every 10 people who fit the definition of amnestic MCI go on to develop Alzheimer’s disease within 7 years,” says the National Institute on Aging.

In contrast, about 1-3% of people above 65 will develop Alzheimer’s each year. This suggests that preventing or mitigating MCI may help delay the onset of age-related brain disorders.

On its own, cognitive decline isn’t life-threatening. One of the core differentiators between mild cognitive impairment and Alzheimer’s is that MCI doesn’t have a major impact on a person’s daily functioning. While Alzheimer’s progressive degeneration makes it hard to maintain a normal life, those with MCI can maintain an independent life through the adoption of healthy habits, which may help reverse early stages of cognitive decline.

Alzheimer’s Disease

 

Aside from memory loss, telltale signs of Alzheimer’s include changes to personality and behavior. Advanced Alzheimer’s patients may also struggle with balance, muscle stiffness, fatigue, and sleep disorders.

This loss of mental acuity and physical functioning, coupled with the presence of abnormal protein clusters and tangles, signifies nerve cell death and tissue loss in the brain. As these changes progress, they cause brain cell degeneration in different areas of the brain responsible for thinking, planning, learning, and memory. Alzheimer’s patients lose their ability to communicate, reason, and recognize loved ones as the brain continues to shrink.

While many people are aware of the mental changes associated with Alzheimer’s, diagnosis isn’t simple. It shares many of the signs and symptoms associated with dementia, tumors, sleep disruptions, and aging itself.

According to New York Times science and medicine reporter Gina Kolata, “A diagnosis of Alzheimer’s disease is not easy to make. Doctors rely mostly on tests of mental acuity and interviews with the patient and family members.” She adds that community doctors may only be about 50-60% accurate in diagnosing the disease. Since Alzheimer’s is so hard to identify, it’s important to have a strong understanding of your own mental acuity — and what you can do to improve it.

How to Improve Mental Acuity

We’ve all heard that eating well and exercising keeps the brain and body sharp. But new research points to specific lifestyle factors that influence cognitive health.

For example, research compiled by UCLA neurology professor Dale Bredesen outlines a list of habits associated with the onset of Alzheimer’s. This includes chronic stress, exposure to mold and environmental toxins, fatty foods, and a lack of exercise and restorative sleep.

Sugar is another hidden culprit: Most people who develop Alzheimer’s also have insulin resistance. While none of these things alone lead to cognitive decline, the compilation of unhealthy activities disrupts the equilibrium of the body and negatively impacts mental abilities. Fortunately, learning how to optimize your brain function through nutrition can help you improve your mental sharpness.

Opt for Brain-Healthy Nutrition

 

If sugar is the worst ingredient for cognitive ability, healthy fats just might be the best. Numerous studies have shown that the Mediterranean diet — high in fresh fruits and vegetables and rich in healthy fats from fish, nuts, and olives — may slow or even prevent Alzheimer’s.

Incorporating these foods into your diet while reducing red meat (even in small amounts) can improve mental acuity, says Dr. Gad Marshall, who works in clinical trials at the Center for Alzheimer’s Research and Treatment at Brigham and Women’s Hospital.

The positive impacts of a Mediterranean diet were reinforced in another recent study, where it was combined with the heart disease diet called DASH (Dietary Approaches to Stop Hypertension) to create the MIND diet. This diet was designed to “place more emphasis on foods that have been linked by previous research to improved cognitive function and delayed decline,” according to Judith C. Thalheimer in Today’s Geriatric Medicine.

The MIND diet recommends eating green leafy vegetables and nuts every day. It also advises eating beans, berries, whole grains, poultry, and fish in moderate quantities throughout the week. While loading up on these brain-healthy foods, you should also limit red meat, pastries, fried foods, and dairy products.

Martha Clare Morris, who led research on the MIND diet, explains that vegetables are especially important for reducing cognitive decline. “Green leafy vegetables show up in research as particularly protective, so we recommend people eat things like spinach, kale, collards, or romaine at least six times a week.” She adds that in animal studies, strawberries and blueberries were associated with improved mental performance.

Work Your Body, Boost Your Mind

 

Regular exercise can make your body strong — but can it also strengthen your mind? This question is being explored by the EXERT study, which is testing exercise as a possible treatment for Alzheimer’s. The approach follows a similar model that pharmaceutical companies use when testing new prescription drugs. Instead of popping pills, participants either hit the treadmill or work on stretching and flexibility.

While the study is still under way, there’s no shortage of research to support it. “The evidence in science has been building for the last 20 years to suggest that exercise at the right intensity could protect brain health as we age,” Baker says.

Other research proves that getting your mental gears turning is just as important as breaking a sweat. Specifically, a Swedish research study on 800 women shows that mental and physical exercises can help maintain mental acuity in midlife. Aside from physical exercises like walking, gardening, or playing sports, the study measured the impact of cognitive exercises like playing an instrument, attending a concert, socializing, or doing needlework.

Engaging in mentally stimulating exercises was shown to reduce the risk of dementia development by 34% in comparison to those who reported fewer cognitive activities. Additionally, regular, intense exercise was associated with a 57% reduction in multiple forms of dementia in comparison to more sedentary people.

These findings show that both your brain and your body need accurate exercise to maintain mental acuity and reduce age-related mental decline.

Maintaining Mental Acuity

Having a sharp mind is important for maintaining a high quality of life as we grow older. Cognitive decline is normal in older adults, but it isn’t entirely unavoidable. An increasingly large body of research shows that specific diets and targeted exercise habits can help reduce instances of cognitive decline.

Measuring your activity levels and revamping your diet could mean the difference between losing your independence and maintaining your freedom. When we can properly reason and remember, we can continue doing the things we enjoy with the people we love.

Reading time: 5 min

Have you ever stopped and wondered how your body produces energy? While the fuel we use to walk and run and lift weights may seem as if it’s coming from nowhere at all, in truth our body is relying on multiple complex systems to produce the energy we need to exercise, walk around, and survive.

As simple as it may seem, even flexing your index finger requires a little bit of energy, and without this energy, we wouldn’t get very far at all. So how exactly does our body go about producing the energy we require? We know that food is a primary source of fuel, but how do we turn the food we eat into usable energy that allows us to thrive?

If we were to break out a microscope and examine our body on a minuscule scale, we’d find that three primary energy systems within our body are working endlessly to carry out this mission. These include the anaerobic glycolysis energy system, the aerobic glycolysis energy system, and the phosphagen system. So what do each of these systems do? Let’s examine them in further detail below.

The Three Primary Energy Systems

The body produces power via three primary energy systems that are also referred to as metabolic pathways. The anaerobic glycolysis energy system does not require oxygen and uses the energy contained within glucose (simple sugars) to form adenosine triphosphate, or ATP for short. ATP is the organic chemical that drives the many processes in living cells because it is a form of energy and is found in all forms of life.

The aerobic glycolysis energy system, on the other hand, requires oxygen to burn fats and carbohydrates for energy but again produces ATP.

But the third and final system, referred to as the phosphagen system, creates creatine phosphate to convert into ATP. Of the three systems that exist, this is the fastest energy system within our body — the energy it produces is immediately available for use.

Today we’re going to focus on that final energy system, the phosphagen system, in more detail. What occurs in the phosphagen system that provides us with energy? And why is this system so important among the three that exist? To find out, let’s take a closer look at the many intricacies of the phosphagen system.

What Is the Phosphagen System?

 

Imagine for a moment that you’re at the starting line for the 100 meter dash. You crouch to the ground and secure your feet against the blocks. From the corner of your eye, you can see the official raise the starting gun. Seconds turn into minutes, and your heart is beating out of your chest as you prepare for the competition that lies ahead. On your marks, get set, GO! The starting gun fires.

You burst from the blocks with explosive power due to your well-established reaction time, catapulting forward as you race down the track. Other sprinters are running at your side using every ounce of strength to overtake you, but slowly you break away from the pack with each stride forward. In a matter of seconds, you’ve crossed the finish line, out of breath and completely drained. The race is over, and you’ve won.

How did it all happen so fast? In the blink of an eye, your body went from a standstill crouched position to throttling forward at top speed, careening down the track as countless muscle contractions and high-intensity energy production took hold. Believe it or not, this was only possible because of one crucial energy system: the phosphagen system.

During short-term, intense activities, the body relies on immediate sources of energy to generate large amounts of power within your muscles. To do so, your body requires an immediate source of ATP — that organic chemical we mentioned earlier whose role is to fuel muscle cells during everyday movements. So where exactly does this immediate ATP energy come from?

The energy we use in the phosphagen system comes from creatine phosphate, also referred to as phosphocreatine or PCr for short. Our body synthesizes creatine phosphate in one of two ways: either from the ingestion of meat, which contains creatine, or from the liver, kidneys, and pancreas, which produce creatine.

Once creatine is absorbed by the body, it’s stored in the skeletal muscles until we need it for energy. To produce creatine phosphate from creatine, our cells use a complex enzyme called creatine kinase that transfers a phosphate group to creatine, thus creating creatine phosphate.

After the body has synthesized creatine phosphate, it can then transfer that phosphate group to adenosine diphosphate, or ADP. ADP differs from ATP because it lacks one phosphate molecule. But this is a crucial point because ADP can’t be used for energy — only ATP can.

After creatine phosphate transfers a phosphate to ADP, it is converted into ATP and is then ready to be used as energy. Thus the phosphagen system is working in natural order, ready to meet our energy needs. But what makes this system so important? Let’s delve into the answer below.

The Importance of the Phosphagen System

Now that we have a basic understanding of how the phosphagen system operates, it’s time to explain why this system is so important.

Take a moment and think back to that scene we painted above where you found yourself sprinting down the track at lightning speed. If we were to classify that form of exercise as either a short-duration exercise or long-duration exercise, chances are you could guess that it would be rather short. It likely takes a mere 15 seconds to travel 100 meters, so it’s very different from the longer periods of time it would take to run a long distance like a mile.

Now think back to the three energy systems we described in detail when we introduced the phosphagen system. Alongside it were the other two energy systems that included anaerobic glycolysis and aerobic glycolysis.

Our body is a rather smart machine that determines when we should use each of these systems. And choosing which one we should use depends on the exercise at hand.

For instance, anaerobic glycolysis is perfectly suited to provide us with energy when we need a large burst of energy that may last anywhere from 30 seconds to 3 minutes at a time. Yet because this system doesn’t use oxygen, lactic acid (one of the many by-products of activity) can build up in our muscles and make them sore, causing us to fatigue and tire.

Aerobic glycolysis, on the other hand, is a system that uses oxygen and is perfectly suited for low-intensity activities that require sustained energy production over longer periods of time, such as running long distances or hiking up the side of a mountain. The energy system our body decides to use is based not only on the exercise, but the exercise intensity as well.

The phosphagen system is so important among these three systems because it is the initial means of energy production that comes before anaerobic glycolysis. It is reserved for high-intensity activities like sprinting or strength training because the ATP it produces is readily available and quickly produced by the body.

Though the phosphagen system will use ATP quickly, ATP production will still remain high when we utilize this system as a means of working muscles via anaerobic exercise.

It should be noted, however, that all of these systems contribute to the overall amount of ATP levels we have during physical activity. Though we may be able to manipulate and biohack our body’s means of using energy, all three systems are still used just the same.

These systems, though different in how they provide energy, do not work independently of one another. Instead, they dominate at different times during a workout depending on the intensity and duration.

Understanding the Three Metabolic Pathways

 

While the phosphagen system is considered an immediate source of energy for our body, in truth we rely upon all three metabolic pathways to produce the necessary ATP molecules that fuel our everyday needs.

From sprinting to walking to simply getting out of bed, a constant stream of ATP is forever pushing us forward. The next time you line up for a sprint or prepare to deadlift a serious set of weights, remember the importance of the phosphagen system and the role it plays in your daily endeavors.

Reading time: 7 min

Each year, thousands of individuals take smart drugs to try and improve their brain power. Nootropics like Adderall, caffeine and Ginkgo biloba are common everywhere from college campuses to high-powered hedge fund offices. These drugs are purported to improve memory recall, increase learning rate and reduce cognitive decline. One of the most popular nootropics is piracetam. It’s a drug that claims to reduce seizures, improve learning disabilities and boost brain function.

Is it the real deal? Like many things that claim to be life-changing, nootropics seem too good to be true. Here, we’ll go over the basics of piracetam from how it works to its benefits and side effects. You’ll learn about the medical research behind the drug and discover other ways you can support your brain health.

What Is Piracetam?

Piracetam, also known by its chemical name 2-oxo-1-pyrrolidine acetamide, is a nootropic drug. Nootropics may help improve cognitive function and can come in the form of supplements, drugs and botanicals. Nootropics are often taken to enhance mood, boost memory recall and improve learning speed.

Research on the efficacy of nootropics is ongoing, but there are some studies that show nootropics may offer minor beneficial effects as a cognitive enhancement. We’ll go over some of that research below, but first, let’s look at the chemical makeup of piracetam.

Piracetam, known by the molecular formula C6H10N2O2, is part of a group of drugs known as racetams. These drugs share a common pyrrolidone nucleus — a 5-armed lactam or ring of hydrogen atom groups. Other drugs in this class include nootropics like aniracetam and phenylpiracetam as well as anticonvulsants.

The special structure of racetams means the drugs can directly impact brain receptors. Drugs like piracetam target AMPA receptors that play a key role in the transmission of signals across synapses in the brain. By stimulating or suppressing certain signal transmissions in the brain, piracetam may help to decrease cognitive impairment and improve mental acuity.

History of Piracetam

Piracetam was developed in the 1950s by Romanian chemist Corneliu E. Giurgea. The drug was derived from the nervous system amino acid known as gamma-aminobutyric acid (GABA). It was designed to help ease symptoms associated with cognitive decline and seizure-inducing illnesses like epilepsy.

In 2004, the United States Food and Drug Administration (FDA) rejected the drug as a dietary supplement. The FDA argues these drugs may prevent individuals from seeking proper medical treatment or may be ineffective. Today, the nootropic can still be found online or in other supplements, though the product technically does not have approval or oversight from the FDA. Piracetam is sold in Europe under the names Nootropil and Lucetam. In Europe, the nootropic is used to treat memory loss, learning difficulties and muscle spasms.

The research on piracetam as an effective cognitive enhancer is limited. We’ll go over the purported benefits and cover the existing studies that show the efficacy of piracetam for certain cognitive disorders.

Uses and Health Benefits of Piracetam

 

While not a new drug, research on piracetam is still not prevalent. Most published piracetam studies are small and poorly designed. Many do not use control groups while others have sample sizes that can’t reflect the benefits of the drug in large populations.

Still, some of the research on this nootropic has discovered interesting potential. Here, we’ll break down the scientific evidence behind the most commonly purported piracetam benefits.

Brain Function

Many manufacturers and users call piracetam and other nootropics “smart drugs.” That term refers directly to the belief that taking nootropics can help boost brain power and improve things like memory recall and attention span.

While there is extensive research on the brain-boosting benefits of other nootropics such as bacopa, piracetam studies are less common. The studies that do exist, show promise when it comes to brain function enhancement. Research also indicates that piracetam may be more effective when paired with choline.

As humans age, cell membranes become more rigid, making it more difficult to process new information. Research also shows that cognitive disorders such as Alzheimer’s disease may reflect a decline in membrane fluidity. Some studies show piracetam may help to protect these cellular structures.

A study published in Biochemical Pharmacology investigated the effects of piracetam on cell membranes in rats, mice and the human brain in a laboratory setting. Researchers found that piracetam increased the fluidity of cell membranes in older rats and mice as well as aged human brains. By improving cell membrane fluidity, piracetam may make it easier for signals to transmit across pathways. The nootropic showed no improvements in young rats or mice.

Another study titled Mechanism of Action of Piracetam on Cerebral Circulation found that piracetam improved blood flow. Scientists believe the improved blood circulation may help to improve awareness and learning. Researchers also noted increased levels of GABA, a neurotransmitter that plays a key role in healthy sleep, stress and anxiety.

Clinical human trials involving the use of piracetam use small study sets but have shown some promise in terms of brain function improvement. One such clinical trial published in Psychopharmacology examined 16 healthy adults for a two-week period. Participants took 400 milligrams of piracetam every day and were instructed to learn a set of new words.

After one week, there was no change in the learning rate. However, after two weeks, researchers found a significant improvement in the ability of participants to learn the word series. It’s important to note that the human study did not include a placebo group for comparison.

Another clinical trial compared the effects of piracetam with a placebo on 18 healthy individuals. During the four-week study, participants were presented with computer tasks. Researchers found that participants who took piracetam performed better on the computer tests compared to the placebo group.

Myoclonic Seizures

A myoclonic seizure occurs when muscle movement is triggered involuntarily. These seizures are unique in that they occur when the individual is awake and lucid. The seizures are relegated to the muscles and produce a shock or lightning-like movement. Small clinical studies show piracetam may help to reduce symptoms associated with these seizures.

A study published in the Journal of Neurology, Neurosurgery, and Psychology investigated the impacts of piracetam on 20 individuals with myoclonic seizures. Under the study design, participants took three different doses of piracetam or a placebo throughout the six-week study. Researchers found that all three doses of piracetam resulted in clinical improvement in motor function, handwriting skill and functional ability.

Another small study investigated the clinical use of piracetam in treating myoclonic seizures. The study assessed 11 patients with myoclonus epilepsy at a severity that disrupted daily activities. Treatment consisted of increasing doses of piracetam with the highest dose consisting of 20 milligrams per day. Researchers found that patients who took piracetam had significant improvement in symptoms 12 months later.

It’s important to point out that the study design allowed patients to continue taking their regular antiepileptic drugs throughout the duration of the trial. This may impact the outcomes, particularly since the study didn’t include a control group.

Learning Difficulties

Some people suffer from learning disabilities that make it difficult to grasp new information or retain details they’ve already learned. Other people suffer from impairments – like dyslexia — that make it difficult to master basic skills such as reading and writing.

Dyslexia affects the language processing area of the brain. People with dyslexia have a hard time identifying speech sounds and may frequently mix up letters or put them in the wrong place when writing. Limited research shows piracetam may help dyslexic students learn more efficiently.

One study examined the clinical applications of piracetam on dyslexia in 225 children. All participants suffered from reading dyslexia and were between the ages of seven and 12 years old. The study excluded children who demonstrated emotional problems, low intelligence and those who had recently taken psychoactive medications.

The children took piracetam or a placebo for the duration of the 36-week study. Researchers found that piracetam produced improvement in reading tests and reading comprehension compared to a placebo starting after 12 weeks of treatment.

A meta-analysis of 11 different studies comprising more than 600 participants also showed the potential of piracetam in treating learning disabilities. The review found that daily doses of up to 3.3 grams of piracetam improved reading ability more dramatically than a placebo.

Cognitive Decline

As we get older, our bodies and brains begin to break down. With each passing year, it’s harder to summit that mountain, learn a new language, or recall information. Cognitive decline is simply a fact of life for most people. Some research shows that piracetam and other nootropics may help to slow this cognitive decline.

Laboratory studies show that piracetam may help to improve mitochondrial function, slowing the breakdown of cognitive processes. A meta-analysis of 19 studies also found significant improvement in patients with dementia or reduced brain function when they took piracetam.

Another clinical trial published in 2000 examined the effects of piracetam on 104 patients with Alzheimer’s disease. Patients started with high doses of piracetam in the first four weeks and then received half the original dose for the remaining two weeks of the trial. Researchers found piracetam improved memory and concentration. These results were more pronounced in individuals who also suffered from depression.

Side Effects of Piracetam

 

While research is limited, most studies show few adverse effects associated with piracetam. Since this drug is not approved for use as a dietary supplement, it’s important to seek medical advice from a qualified healthcare professional before ordering these nootropics on the internet. Your healthcare provider can help you understand the benefits and side effects associated with nootropics like piracetam.

The most common side effects reported in studies of piracetam include nausea, headaches, diarrhea and exhaustion. Piracetam may also interact with blood thinners and other heart disease medications. Pregnant women or women who are nursing should not take piracetam.

Support Your Brain by Living a Healthy Lifestyle

Piracetam is a nootropic that is marketed as a brain-boosting drug. It’s not approved for use as a dietary supplement in the U.S., but it is prescribed for brain function in Europe. Research on its efficacy is limited, but there are still many things you can do to support your brain health.

Eating a nutritious diet ensures that your brain and body get many of the essential vitamins and minerals needed for optimal function. Keep in mind, that due to the current farming practices and highly depleted US soils, it is recommended to get regular blood work done, so you can detect should you have any mineral or vitamin deficiencies.

Additionally, exercising can also help improve circulation and train your mind and body for endurance and focus.

Getting the right amount of sleep can make the difference between clarity, mental focus and feeling sluggish. You can use the Biostrap Recover Set to track your sleep and get a better understanding of your health thanks to clinical-quality analysis of your heart, respiratory system and mental acuity.

Reading time: 4 min

If you’ve ever seen Pulp Fiction you’ll likely not forget the scene where Uma Thurman’s overdose is reversed with a shot of adrenaline to the heart; wide-eyed, she bolts upright with a gasp.

“I’m an adrenaline junkie,” people say, as they thrill-seek their way across the globe, bungee jumping, diving off cliffs, swimming with sharks.  Drawn to danger, they revel in that heart-in-your-throat, blood pumping feeling.  Not everyone shares their enthusiasm.  But what is adrenaline, exactly? And what does it do?

What is Adrenaline?

One of the most interesting things about adrenaline,” says Baltimore endocrinologist Mansur Shimali, “is that it can be both a hormone, and a neurotransmitter.

Adrenaline, also known as epinephrine, is our “fight-or-flight” hormone”, says Michael R. Rickels of University of Pennsylvania Perelman School of Medicine.  “It increases heart rate and contractility in order to get our blood pumping and oxygen to our muscles and brain under conditions of physiologic stress, and will help to maintain blood pressure during blood loss or dehydration.

Adrenaline is a survival hormone.  It helps us be fast or strong under threat.  When humans encounter danger, we have two options: fight off the predator, or run for the hills. Each of these responses requires muscle strength.  When our amygdala senses danger, it reaches out to the hypothalamus,  Adrenaline then triggers the physiological changes our body will need to attack, defend, or run away.  Even before we react, or choose a course of action, our heart is already rushing oxygenated blood to our muscles, so we’ll be ready.

On your mark, get set, Go!

In early humans, adrenaline provided a survival mechanism to fight off foes, and win competition for food, land or mates. But the adrenaline response is not limited to predator danger.

At the start of a sprint, as runners hear, “On your mark!  Get set!”, they crouch, ready to run.  Their hearts race. Their muscles twitch. Adrenaline is coursing through their blood, ensuring that when they hear the command “Go!” they are prepared to race for their lives (or at least a medal). Adrenaline powers our performance whether the external stressor is unexpected (a pouncing tiger), sought-after (hang-gliding) or self-imposed (athletic competitions or haunted houses).

Effects of Adrenaline?

The immediate impact of an adrenaline surge:

  • Eyes dilate.
  • Heart beats faster.
  • Sweat increases.
  • Bronchioles dilate (so we can get more oxygen).
  • Blood vessels dilate (enlarge) in our muscles.
  • Blood vessels constrict in our digestive tract to slow digestion.
  • Kidneys make more renin (to increase blood pressure).
  • Glucose production increases, for energy.

Each of these responses is tailored to focus the body’s resources on survival.

Where does adrenaline come from?

Adrenaline is a creation of the nervous system.

The human nervous system is divided into two sections:

  • central nervous system
  • peripheral nervous system

The peripheral nervous system has two subsystems:

  • somatic nervous system (our voluntary movements).
  • autonomic nervous system (unconscious operation of  heart, digestion and breathing).

The autonomic nervous system has three components:

  • sympathetic (stimulates ‘fight or flight’).
  • parasympathetic (“breed and feed” or ‘rest and digest’).
  • Enteric (“second brain”).

Sympathetic Nervous System (Fight or Flight)

Our sympathetic nervous system is the center of our ‘fight or flight’ response, that ancient reaction to danger which enabled our ancestors to outrun, outmaneuver and outsmart predators.

The sympathetic nervous system is always mildly activated, ready. It manages stress, and returns the body to homeostasis, through the activation (or inactivation) of the adrenal gland.

Adrenal Gland

Adrenaline is manufactured within our adrenal glands. There are two.

Each adrenal gland sits atop a kidney. (The word adrenal literally means at (ad) the kidney (renal).

The adrenal gland has two sections.

  • Adrenal cortex (outer portion)
  • Adrenal medulla (inner portion)

The adrenal cortex produces cortisol (another stress hormone), which regulates metabolism.  Aldosterone, which helps control blood pressure, is also secreted here.

The adrenal medulla.  It’s here that adrenaline (a catecholamine:) is generated to help you fight tigers, or meet that deadline. Unlike the adrenal cortex, the adrenal medulla is not essential to human life.  The adrenal medulla connects to the sympathetic nervous system via a sympathoadrenal system that regulates the stress response.

Adrenaline and Diabetes

But adrenaline is more than a spur to physical exertion.  “Adrenal hormones also regulate salt and water balance in the human body,“  says Dr. Shimali, “They do that by signaling to the kidneys.

Adrenaline also affects metabolism”, says Dr. Rickels, “releasing fatty acids from fat tissue that our muscles can burn, and releasing glucose from our liver that on which our brain depends, and so helps to maintain blood glucose levels during prolonged fasting or periods of famine.

This is especially significant for diabetics. “Adrenaline features prominently in the defense against low blood glucose (hypoglycemia)”, says Dr. Rickels, “and is thus critical for patients with insulin-dependent diabetes to help them avoid severe insulin reactions that can result in loss-of-consciousness, or seizures.”

Other health applications

But there are medical applications as well. Supplemental adrenaline is used widely, for a variety of reasons, in sometimes unexpected ways.  Did you ever sit in the dentist’s chair, lip puffy with novocaine, heart pounding as the dentist approached you with a drill?  It might not be your fear itself, making your heart pound. Dentists add epinephrine (adrenaline) to novocaine, to staunch bleeding and make the effects last longer.

Adrenaline (epinephrine) has also saved countless lives by reversing anaphylactic shock from allergic reactions. It restarts hearts after cardiac arrest.  It is used daily to ease breathing in asthmatics or children with croup.  It reverses blood pressure due to blood loss.  Spikes in adrenaline have also been linked to early morning cardiac events. Adrenaline even plays a role in our circadian rhythm  Despite this significant impact on medicine, no Nobel Prize was ever awarded in connection with adrenaline’s discovery.

It’s a hormone. It’s a neurotransmitter. It’s a life-saving intervention. It’s a blast! For something deemed ‘non-essential to human life, adrenaline certainly has a key role to play in our physical performance, stress mediation, and the quality of our life.

So when confronted with danger, whether we decide to fight or run, the physiological changes are the same. Cowards and warriors alike have adrenaline to thank for fueling choices made in an instant. And that adrenaline rush you feel? Some people even pay for that.

Reading time: 5 min

Have you ever blocked someone on social media so they couldn’t send you a message? GABA, an amino acid, works a lot like this feature. It prevents certain brain signals — most notably fear and stress — from reaching your brain and wreaking havoc throughout your nervous system.

This is why people who suffer from chronic stress and anxiety disorders use GABA to find relief. But that’s only half the story, and it’s important to understand how GABA works in the brain if you’re interested in its effects.

So what is GABA and what does GABA do to the brain? Read on to find out the life-changing possibilities of adding GABA to your wellness routine.

What Is GABA?

GABA (gamma-aminobutyric acid) is an amino acid and a primary inhibitory neurotransmitter in the brain. Ordinary neurotransmitters send chemical signals to the brain to elicit certain responses that keep the body safe and healthy.

GABA is considered an inhibitory neurotransmitter because, instead of sending a signal to nerve cells, it prevents a signal from being sent. There are two main types of GABA, GABAA and GABAB, and both play an important role in mood regulation. GABA attaches to protein receptors in the brain called GABA receptors to slow or inhibit activity, says Dr. Michael Breus, The Sleep Doctor.

“GABA’s big role in the body is to reduce the activity of neurons in the brain and central nervous system, which in turn has a broad range of effects on the body and mind, including increased relaxation, reduced stress, a more calm, balanced mood, alleviation of pain, and a boost to sleep,” he explains.

So what kind of activity does GABA keep from reaching the brain? Think excitatory neurotransmitters — anxiety, stress, and fear are all signals that GABA blocks. Instead of allowing these messages to reach brain cells, GABA binds to GABA receptors to promote relaxation, reduce anxiety, improve mood, and boosts social skills.

Most of us aren’t new to the effects of GABA. Alcohol is a GABA activator — that’s why it makes us feel so happy and social (if only for a short while). Anti-anxiety drugs also bind to GABA. In fact, most of the leading drugs prescribed to treat anxiety are GABA activators.

What Does GABA Do?

 

Since GABA soaks up adrenaline and related stress chemicals, people with low GABA will feel the effects of stress and anxiety more intensely and more often. Low GABA activity has been shown to exacerbate mental illnesses, including depression, social anxiety disorder, and post-traumatic stress disorder (PTSD). Symptoms of low GABA include feeling disorganized, having racing thoughts, increased heart rate and being unable to relax or get restful sleep.

In addition to influencing anxiety, low GABA plays a role in certain medical disorders. Seizures and ADD are both linked to low GABA, for example. People who have Illnesses that affect their motor skills, like Parkinson’s, also tend to have low GABA levels.

People with low GABA activity can benefit from supplements or adding GABA to their diet. By switching the brain back into low gear, GABA can have a profound effect on a person’s feelings. It induces a calm and relaxed emotional state in a sea of worry.

GABA for Anxiety

The role of GABA in anxiety cannot be understated. According to a 2019 study published in Cellular Neuroscience, new approaches to GABA treatment have the potential to reduce major depressive disorder (MDD) even more quickly than current anti-depressants on the market. While it’s clear that GABA promoters reduce anxiety, it’s important to take care when considering such medications. Using synthetic drugs may result in additional side effects that can exacerbate stress or lead to other struggles.

GABA for Sleep

The effects of GABA can also improve sleep (common sleeping pills like Ambien also bind to GABA receptors). Sleep research shows that people who suffer from insomnia have 30% lower levels of GABA in their brains compared to people without sleep disturbances. Moreover, these low GABA levels persisted even after waking, confirming that poor sleep plays a role in daily mood.

Though it was a small study, these results are promising. They suggest that even people without insomnia or other sleep disorders may find that increasing GABA reduces daytime sleepiness.

GABA for Gut Health

The gut and the brain are inextricably connected, so it’s no surprise that GABA affects digestion. Dr. Will Cole, a functional medicine expert and natural healthcare advocate, explains that improperly-functioning GABA cells in the brain can wreak havoc in the gut.

“Your intestinal lining also has its own GABA receptors, which help to digest food and regulate gastrointestinal activity by producing gastric acid.”

He adds that certain bacteria strains have been shown to boost GABA receptors in the gut, suggesting the importance of maintaining a healthy gut microbiome.

Adding GABA to Your Life

 

Introducing more GABA into your life through dietary changes or supplements has the potential to reduce the constant state of stress and anxiety in the brain and restore homeostasis. Even if you don’t suffer from anxiety, supplementing with GABA can make you more resilient against stressful events when they occur. And GABA may also protect you from diseases like Parkinson’s and other motor skills or mood-related disorders.

GABA Supplements

GABA supplements have risen in popularity as an alternative to common prescription antidepressants. Picamilon is a popular synthetic drug that crosses the blood-brain barrier and is converted to GABA to induce a calming a soothing effect. Phenibut is similar, yet with stronger anti-anxiety effects. It’s unregulated in the United States.

Despite the increasing demand for manmade GABA producers, consumers should proceed with caution. Since there isn’t enough research to determine the long-term effects of GABA supplements and whether or not they cause dependency, using natural brain-enhancers to promote GABA instead may be a safer alternative.

Herb and Root Sources of GABA

 

There are many naturally-occurring sources of GABA, aside from those found in food. Take the herb valerian root, for example. It’s common as a natural sleep and relaxation enhancer but has also been shown to increase GABA. Kava is another popular treatment for anxiety that has been shown to have a strong calming effect. Studies show that kava makes people feel more relaxed and social because it binds to GABA receptors, producing a sedative effect.

Further research confirms that botanical anxiolytics (herbs that treat anxiety) stimulate GABA receptors. Specifically, St John’s Wort and Ginkgo Biloba were found to reduce the effects of psychiatric disorders, including anxiety.

“In this regard, anxiety may be managed without the harsh side effects of pharmaceuticals using nutritional and botanical treatment as well as lifestyle changes,” write the study’s authors. Lemon balm, ashwagandha, and jasmine have all been cited as additional GABA enhancers.

Dietary Sources of GABA

We’ve touched on the importance of gut bacteria in maintaining healthy GABA levels. That’s why adding more healthy bacteria into your diet is a smart way to support GABA production. Studies show that fermented foods like Miso, kimchi, and tempeh may result in the direct production of GABA.

Other studies show that consuming certain GABA-promoting foods, rich in healthy bacteria, helped people fall asleep faster. By decreasing inflammation, reducing intestinal permeability (leaky gut), and improving gut-to-brain communication, the microbiota found in these foods also have the potential to restore gut health overall.

Get More GABA to Feel Good

It’s clear that GABA plays an essential role in helping us feel relaxed and content. Having low GABA can cause a host of negative effects — from depression and anxiety to seizures and Parkinson’s disease. Fortunately, nature provides a host of GABA supplements that can be ingested through herbal remedies or nourishing foods. Synthetic GABA sources are also available but should be used with caution and with professional medical advice. Adding GABA to your life can help you get healthy, reduce panic, and invite more calm and serenity into your daily experience.

Reading time: 5 min

The body utilizes three principal macronutrients to ensure it remains properly fueled at all times: carbohydrates, fats, and protein. Each of these fuel sources burn off on a predictable spectrum where each source serves a specific purpose.

Carbohydrates, for instance, act as an immediate fuel source that we use often throughout the day. Fats act as a reserve fuel source and are burned during bouts of low-intensity physical exercise or if our stores of carbohydrates are depleted. And finally, proteins are used to build and repair tissue, as well as make enzymes, hormones, and other body chemicals.

But what would happen if we chose to manipulate how our body uses its fuel? Often we do this by employing diets that limit our intake of certain macronutrients, thus making us more dependent on the other macronutrients. One of these diets is called the ketogenic diet — a popular diet that stresses eating an extremely limited amount of carbs (or no carbs at all) in order to burn more fats.

As a result of the ketogenic diet, or keto diet for short, the liver breaks down the fatty acids in fats, and creates ketone bodies as a result. These ketone bodies are individual, water-soluble compounds that serve as fuel for the brain, heart, and muscles in times when carbohydrates are in short supply. And the predominant ketone body that accounts for upwards of 78% of all ketone bodies in the blood is called beta-hydroxybutyrate, or BHB for short.

So why is this ketone body so important, and why do we produce so much of it? What purpose does it serve, and why should we care how much our bodies are making? To find out more, let’s dive deeper into the world of fats, ketone bodies, and BHB.

Let’s Talk About Ketosis

Now before we take a blind leap into the world of Beta-hydroxybutyrate, we need to first discuss the normal metabolic process of ketosis. Ketosis occurs whenever the body is running low on glucose from carbs, and therefore, can’t rely on glucose as a source of energy. At times like this, the body shifts to burning fats instead, and the process of ketosis takes place.

When the body burns fats for fuel, a build-up of acids called ketone bodies (or ketones, for short) will accumulate and must then be converted into fuel. Ketosis is often considered a healthy process because it induces weight loss, lowers blood sugar levels, and reduces seizures in epileptic children. Yet for a small portion of the population, ketosis can pose a risk if left uncontrolled.

For instance, those who suffer from type 1 diabetes can encounter diabetic ketoacidosis, a complication in which the body’s insulin deficiency causes ketone bodies to build up in the blood. When this occurs, the blood becomes acidic and systems within the body can’t function properly.

But for others, ketosis serves as a weight-loss method and can even be rather healthy. When ketosis takes place, BHB is produced as a result.

So What Is Beta-Hydroxybutyrate and What Does It Do?

As stated in brief detail above, BHB stands for beta-hydroxybutyrate, and it serves us as the most abundant ketone body of the three that are produced by the liver during the process of ketosis.

Beta-hydroxybutyrate is so special because of what it can do when our accessible calories from carbs run low. These calories may run low for a number of different reasons that include exercise, fasting, caloric restriction, or following a special diet plan like the keto diet. But when they do run low, BHB levels increase in the brain, heart, muscles, and other tissue.

So what does BHB do exactly? Ultimately, it serves as a crucial source of fuel for countless systems within our body, and provides us with a number of potential benefits. Let’s discuss what those benefits are in more detail.

Benefits of BHB

 

As the primary ketone body found in the blood during the process of ketosis, BHB serves us principally as a fuel source. During the process of breaking down this ketone, BHB is used as fuel by the mitochondria after being converted into acetoacetate and then to acetyl-CoA, an enzyme that works endlessly during metabolic processes to provide us with energy.

Additionally, beta-hydroxybutyrate acts as a powerful energy source for our brain. Because BHB can easily cross the blood-brain barrier, it’s particularly well-suited to providing the brain with energy. It should be noted, however, that BHB does more for our brains than simply provide them with fuel.

Beta-hydroxybutyrate can also trigger the release of chemicals called neurotrophins, which support neuron function and synapse formation. Research indicates that one of the neurotrophins BHB triggers is associated with cognitive enhancement, alleviation of depression, and reduction in anxiety

Measuring BHB in the Blood

In order to ensure the body remains in a state of nutritional ketosis, those who are strongly committed to the ketogenic diet need to regularly measure blood ketone levels to verify the presence of ketones in the blood, urine, and breath.

To do this, we can employ the same equipment used during diabetes care. A handheld blood glucose monitor is the most commonly used tool for the job because it has the ability to measure blood ketone levels with ease. And of the three ketone bodies that exist (BHB, Acetone, and Acetoacetate), BHB is the only ketone body that can be measured in the blood with a simple finger prick.

Acetoacetate is measured in the urine with a dipstick device, as urine ketones are commonly excreted during ketosis. And Acetone is measured in the breath (though this is more difficult to measure and a fairly uncommon thing to track even for the most dedicated keto practitioners).

Using Ketone Supplements

 

Employing low-carbohydrate diets or limiting carbohydrate intake are not the only ways to induce a state of ketosis. While we may consume high-fat foods as a means of lowering glucose levels endogenously (internally), we can also consume ketone supplements that seek to mimic ketosis and raise blood glucose levels without actually having to change our diet. These are called exogenous ketones.

There are two main forms of exogenous ketone supplements that seek to make this possible: ketone salts and ketone esters. Ketone salts are simply ketone bodies bound to a salt such as sodium, potassium, calcium, or magnesium. They’re most often found in powder form rather than mixed with liquid.

Ketone esters, on the other hand, are linked to a compound called an ester and are packaged in liquid form. These are used more commonly during research and aren’t as readily available as ketone salts.

The other primary reason we may use ketone supplements is in conjunction with the ketogenic diet. By taking these supplements, we actually stand to reduce the time it takes to enter a state of ketosis, which lessens the unpleasant side effects that can come from transitioning from a standard, higher-carb diet to a ketogenic one.

Potential Side Effects of the Ketogenic Diet and Ketone Supplements

As is the case with most diets and dietary supplements, side effects may occur and should be taken into account. For instance, the ketogenic diet may induce what’s known as the “keto flu.” Symptoms of this flu include constipation, headache, bad breath, muscle cramps, and diarrhea. Though these symptoms will subside over time.

Exogenous ketone supplements, on the other hand, may suppress appetite or even inhibit fat breakdown. Evidence does not fully support the use of ketone supplements, and further research is necessary to ensure they’re safe for long-term use and perform the tasks they claim.

And because ketone supplements are attached to a salt, they actually contain calories. As a result of this, you may be consuming more calories as you take repeated doses of ketone salts throughout the day to remain in a state of ketosis.

Beta-hydroxybutyrate, Ketosis, and You

When all is said and done, undergoing the process of ketosis allows your body to produce and utilize the three main ketone bodies that are fit for fuel. Of these three, BHB is a powerful ketone body that can provide a number of helpful benefits should you choose to utilize the ketogenic diet as a means of biohacking your body and losing weight. That said, it’s important to speak with your healthcare provider to determine whether entering a state of ketosis is right for you.

Should you receive the all-clear to adopt the ketogenic diet, remember the side effects that may occur and be prepared to experience the “keto flu.” And as your body receives fuel from those powerful ketone bodies, also remember to thank beta-hydroxybutyrate for all the good it can do along the way.

Reading time: 5 min

Too much salt is bad for you. Everyone knows this. Lose the salt shaker, we’ve been told, by our doctors. Our mothers. The government. Our trainers. Turns out, maybe we should take this advice with, er, a grain of salt. That is, with skepticism.

In a new book The Salt Fix author James DiNicolantonio comes out swinging. Subtitled Why the Experts Got It All Wrongand How Eating More Might Save Your Life, the book lays out the case that medicine has been ignoring its own research. Study after study, he says, shows the dangers of salt consumption are exaggerated, the risks of a low salt diet understated, and, when it comes to government recommendations? The numbers are just plain wrong.

What is Salt?

Salt (NaCl or sodium chloride) is a mineral made up of equal parts sodium and chloride. Most commercial salt is harvested through mining or solution mining existing salt deposits. Salt occurs naturally throughout the world and is necessary for all life.

Do a quick Google search on ‘tips for heart health”. Nearly every search result will tell you to reduce or eliminate the salt in your diet. Authorities firmly on the no-such-thing-as-good-salt bandwagon include Harvard the British National Health Service, the CDC Centers for Disease Controls and Prevention (CDC), Health.gov and the American Heart Association. The CDC has launched a Sodium Reduction Initiative.

And for people with existing high blood pressure, salt is a serious irritant. Salt reduces their kidneys’ ability to remove water. This extra fluid strains blood vessels and can elevate blood pressure further.

What’s the deal with blood pressure?

Blood pressure is the measurement of blood moving through the circulatory system. It is measured by two numbers: systolic (the top number, is the pressure in your blood vessels while your heart beats) and diastolic (the bottom number, is the pressure as your heart rests between beats). A normal range is systolic under 120 mmHg and diastolic reading under 80 mmHg. (120/80.) Hypertension (high blood pressure) is diagnosed when systolic exceeds 140 mmHg. Or diastolic tops 90 mmHg.

High blood pressure increases the long-term heart risk and stroke. Dangerously high blood pressure raises the immediate risk of stroke, heart attack, organ failure or death. Low blood pressure can also signify a problem. Plummeting blood pressure from any cause is a life-threatening emergency.

Blood pressure is affected by the heartbeat and the width and elasticity of our arteries. Salt and potassium also work together to regulate blood pressure and circulating blood volume.

Without salt, our bodies could not sustain blood volume. Our blood vessels would literally collapse, leading to circulatory collapse, hypovolemic shock and eventually death.

How Much Salt is Too Much?

Nutrition and health are closely related. Given the demonstrated connection between high blood pressure and poor cardiac outcomes, health officials have sought behavioral interventions to lower blood pressure. Salt, known to raise blood pressure in people with already high blood pressure, was an obvious target. Salt began to be seen as bad in general. The 2015-2020 Dietary Guidelines for Americans recommend less than 2.3 grams of sodium per day. The average American now eats 3.4 grams.

Some people are salt sensitive. High salt intake raises their blood pressure. A low salt diet decreases their blood pressure. Other folks are salt resistant. It’s not clear why. There is no unified theory of what causes high blood pressure. We do know that there is a connection between blood pressure and the ability to maintain core body temperature.

But for people who aren’t salt sensitive, restricting salt intake may not make sense. DiNicolantonio, author of The Salt Fix, says our relationship with salt is ancient as we “evolved from the briny sea”. He posits that healthy adults should actually be consuming 3 to 6 grams, more than double the current recommended limit.

Salt plays a key role in blood volume, hydration, electrolyte balance and general homeostasis.

Salt and our resting heart rate

When exercising, a healthy heart can even double its heart rate and still not cause an unhealthy rise in blood pressure. Blood vessels just get larger (dilate) to allow increased flow. But what about our resting heart rate?

Resting heart rate is a key measure of our overall health. The lower the better. DiNicolantonio is a cardiovascular research scientist and doctor of pharmacy, We reached out to him to ask about the impact of salt on our resting heart rates. “Low-salt diets have been found to increase heart rate in humans in several studies,” he said.

What about heart rate variability?

Heart rate variability (HRV) is the diversity of spacing between each heartbeat. High HRV is a marker of cardiac health. People with high blood pressure have decreased HRV. So what is the role of salt intake in HRV?

Sodium balance and related changes in plasma volume help determine our HRV. High salt diets might affect people with high blood pressure differently, including their HRV. “The data on heart rate variability are less consistent,” says DiNicolantonio, “but it is possible that by chronically stimulating the sympathetic nervous system low-salt diets may lead to altered heart rate variability.”

One study of heart rate variability centered on salt sensitivity and blood pressure. Researchers found that the body makes adjustments to regulate blood pressure. When salt intake is low, the heart and peripheral vasculature increase cardiac activity and vascular tone. When salt intake is high, the body decreases cardiac activity.

New areas of study

In 2014 The National Heart, Lung, and Blood Institute (NHLBI) convened to examine Salt’s Effect on Human Health. This working group “identified scientific gaps and challenges and highlighted some opportunities for scientific inquiry and technical development” concluding, “the initial research that implicated salt as a factor in important diseases points to the need to further illuminate the biological mechanisms and pathological processes to which salt may contribute”.

Specific areas for further study include the role of hypertension in autoimmune diseases; salt-sensitive hypertension; how we store salt in our skin; how to determine salt sensitivity at an individual level; new technologies to measure sodium concentrations in human tissue; and even a Sodium MRI to help reveal the role of salt in health and disease.

DiNicolantonio links low-sodium diets to medical risks including obesity, heart failure, and kidney disease, concluding “overconsumption of salt is not the primary cause of hypertension”.

“Salt restriction. “ he says, “may actually worsen overall cardiovascular health. and may lead to other unintended consequences (insulin resistance, type 2 diabetes, and obesity).”

He just performed an overview of existing research entitled, Is Salt a Culprit or an Innocent Bystander in Hypertension? A Hypothesis Challenging the Ancient Paradigm The study highlights a substantial body of peer-reviewed evidence, and concludes that high salt consumption is not always bad, and low salt diets are not always a panacea. Salt intake is a proven risk for folk who already have high blood pressure. The rest of us could be eating salt (within reason). A low salt diet, says DiNicolantonio, is even potentially heart harmful.

So who’s right? Looks like the debate will continue for a little while longer. In the meantime, know your risk factors, check your blood pressure, monitor your heart rate, get plenty of exercise, and don’t go overboard on the salt. But you might not need to skimp on it either.

Reading time: 4 min

 

“Spaghetti LEANguine” – that’s what kids used to call Sam back in middle school. He always stood with his back hunched, towering above all the other teenagers around him. Right now, he’s 27 years old, stands 6 feet tall, and works at one of Fortune 500’s companies.

No one has called Sam ‘spaghetti linguine’ in years. But on occasion, he heard this remark from a new acquaintance:

“Wow. You are so tall. And SO skinny.”

He hated his scrawny and lanky body. He loathed being introduced to new people – he knew it was only a matter of time before he’d hear that dreaded comment he was all too familiar with his entire life. Last year, he decided enough was enough. He hit the gym nearly every day, strength trained hard, and dialed in on his diet. Over time, he steadily gained lean muscle and dropped his body fat percentage below 10%.

Pete (a short, pudgy 29 year old guy) is Sam’s coworker. They worked in the same department and ran into each other on a daily basis. Pete noticed Sam’s transformation and was shocked by Sam’s progress.

“Sam, what’s your secret? Tell me EXACTLY what you did because I want to lose my belly fat and get into better shape.”

Enthusiastically, Sam shared with Pete his gym routine, what to eat, and what not to eat. Pete followed Sam’s advice and adhered to all directions – especially Sam’s diet tips.

After 3 months, Pete saw his own transformation. But not in the way you would expect.

Pete felt strong – He was able to lift a lot heavier than before. But he didn’t look leaner. In fact, he appeared a bit fatter.

Pete was incredibly upset and demoralized: “I followed everything Sam told me to do! I worked out regularly. I ate clean! I ate tons of chicken, rice, and broccoli! Why don’t I have a fit body?”

Why didn’t Pete getting the same results? What went wrong?

The simple answer: calories.

Calories and Macros

But let’s investigate this conundrum in detail. Calories is only one puzzle piece to the big picture.

Another crucial factor that must be accounted for is macronutrients. Counting macronutrients (generally referred to as macros) has gained popularity over the past few years. There’s even a niche for this lifestyle called IIFYM – If It Fits Your Macros.

Here’s the cold-hard truth: there is no perfect macro ratio. The human body is complex. A plethorna of variables (such as sleep, accurate activity tracking, the quality of the food you eat, etc.) contribute to long term changes. What works for one person may not necessarily work for another. Everyone has different genes, lifestyles, and goals. The best approach to figuring out your macro ratio is to follow a guideline (based on your phenotype) and tweak it as you go.

But before figuring out which macro ratio is optimal for you, it’s important to understand what macronutrients are and how they function in our bodies.

What Are Macronutrients?

Macros are the chemical compounds you ingest. When you look at a nutrition label, it displays how many grams of each macro – carbohydrates, proteins, and fats – are in a single serving. Macros plays numerous roles in the optimization of the body. Dr. Josh Axe, DNM, DC, CNS, explains that “We cannot live without all three of these macronutrients even for a short period of time, as they’re needed for everything from growth and development to sustaining circulation and providing the brain with enough energy for cognitive functioning.”

Major function of each macronutrient:

  • Carbohydrates (glucose) –  body’s #1 source for energy. Used immediately. Stored away in muscles or fat for later use
  • Proteins (amino acids) – builds and maintains lean muscle mass
  • Fats (fatty acids) – regulates hormones

All macros fuel our bodies with energy.

  • 1 gram of carbohydrate = 4 calories
  • 1 gram of protein = 4 calories
  • 1 gram of fat = 9 calories

From a weight gain or weight loss perspective, macronutrients correlate with calories. Body composition, on the other hand, may be altered by macro ratios.

The Best Macro Ratio Based on Your Phenotype

The physique of a 21-year-old, male football player looks significantly different from a sedentary, 52-year-old female. Every person fits into one of these body types: ectomorph, mesomorph, and endomorph. Some individuals are a combination, depending on their body composition. Therefore, it would be ineffective to apply a ‘one shoe fits all’ method to macro ratios. You may have to modify your macro numbers based on how your body reacts to different macronutrient percentages.

But everyone has to begin from square one. Where you start is just as important as taking the first step. These 3 macro ratios (based on your phenotype) can help save time and errors in your health and fitness journey. Obi Obadike, MS., ISSA Certified Fitness Trainer and Nutrition Specialist, recommends the macro ratios listed below as a foundation.

Body Type #1: Ectomorph

From the story above, Sam represents the classic ectomorph.

  • Skinny
  • Narrow frame
  • Has difficulty gaining weight (muscle or fat)
  • Speedy metabolism
  • High carbohydrate tolerance

Macro Ratio for Ectomorphs

  • 55% carbohydrates
  • 25% proteins
  • 20% fats

Body Type #2: Mesomorph

Mesomorphs have an athletic and muscular body.

  • Wider shoulders & smaller waist
  • Gains muscle easily
  • Can gain fat more easily than an ectomorph
  • Symmetrical frame

Macro Ratio for Mesomorphs

  • 40% carbohydrates
  • 30% proteins
  • 30% fats

Body Type #3: Endomorph

Using the story from above once again – Pete represents the endomorph.

  • Gains fat easily
  • Gains muscle easily
  • Larger frame
  • Has difficulty losing weight
  • Low carbohydrate tolerance

Macro Ratio for Endomorphs

  • 25% carbohydrates
  • 35% proteins
  • 40% fats

If your body type is similar to Pete’s, don’t eat like Sam. That’s a formula for disaster.

Tools to Help Configure Your Macro Numbers

Calculating Your Macro Numbers

It is entirely possible to calculate out by hand the number of carb, protein, and fat grams you need each day. This allows you flexibility and complete autonomy over the numbers you’d like to input.

But this is also time-consuming and tedious for many. There are plenty of tools online to compute your macro numbers. Many of these sites also take your goals (fat loss, maintenance, or muscle mass gain) into consideration. Here’s a couple:

  • If It Fits Your Macros – This calculator is the most comprehensive if you’ve never calculated your macros before.
  • Katy Hearn Fit – This one allows you to customize your nutrition plan. You can choose how many grams of protein and fat you’d like to allocate per lb. of body weight.
Reading time: 5 min

Slowing down mentally and physically is a normal side effect of aging. But what if someone told you that these unwanted experiences could be greatly reduced or even delayed? Enter: myelin repair. As more studies reveal the role of myelinating cells in a healthy brain and body, more people are asking how to increase myelin to boost their longevity.

So what exactly is myelin and the myelin sheath, and what do these things mean for living your best life? Here, we outline everything you need to know about myelin loss and myelin repair, including how to create new myelin for a sharper, healthier, and longer life.

Myelin and the Nervous Systems

 

Learning how to increase myelin starts by learning the role of myelin in the body’s nervous systems.

The central nervous system, or CNS, comprises the brain and spinal cord, and is responsible for controlling all major bodily functions. Voluntary movements, speech, thought, memory, and spatial awareness are all controlled by the CNS.

In contrast, the peripheral nervous system comprises all of the nerves outside of the brain and spinal cord, such as those that connect the limbs and organs.

The nervous system gets its name from neurons, which are responsible for transmitting electrochemical signals throughout the body. Neurons send messages from the brain to enable us to think, act, feel, and interact with the world around us.

What Is the Myelin Sheath?

So where does myelin fit in? Myelin in the central nervous system is produced by oligodendrocyte progenitor cells, also called oligodendrocyte precursor cells or OPCs. Oligodendrocytes are a type of glial cell that helps create the myelin sheath, the fatty coating around nerve cells keeping them insulated and protected.

Schwann cells, located in the peripheral nervous system, also support axonal myelin formation. Myelinated axons exist primarily in the brain’s white matter. Myelin is critical for quickly conducting messages throughout both nervous systems.

When functioning properly, myelin protects nerve cells as they transmit signals from the brain to organs, muscles, and systems throughout the body. The myelin sheath, or myelin membrane, also ensures that impulses are effectively delivered from the brain and spinal cord to the rest of the body.

Myelin Loss, Multiple Sclerosis, and Aging

Multiple Sclerosis is an autoimmune disease that attacks the myelin sheath in the central nervous system. Myelin damage, also called demyelination, leaves the nerve cells unprotected, where they then experience damage. In addition to causing damage along the nerve fibers, MS also halts new myelin production by destroying OPCs.

Myelin loss leads to delays in messaging from the nerve impulse, which results in the common symptoms of MS: vision problems (due to optic nerve issues), tingling, numbness, fatigue, and dizziness.

Loss of myelin also occurs naturally as a result of aging, as explained in a study on myelin and nerve fibers. Changes in nerve impulse conduction in the central nervous system is one reason why aging is associated with cognitive decline. Poor eating, exercising, and sleeping habits also play a role in increased demyelination, as explained further on.

How to Increase Myelin

 

Heavily myelinated neural pathways function up to 300 times faster than cells that have experienced neurodegeneration. This helps us move more quickly and make smarter decisions. These optimized neural pathways also help us become more emotionally agile, boosting our resiliency against life’s greatest challenges.

It’s clear that myelin is important for living a healthy and fulfilled life. But in some cases, such as an immune system disorder like multiple sclerosis or other demyelinating diseases, demyelination is unavoidable.

The good news? The same study we mentioned earlier on myelin and nerve fibers revealed that OPCs increase with age, suggesting that myelin production can still occur at any point throughout our lifetimes, even in spite of neurodegenerative diseases. Further studies have shown that the act of repairing myelin (remyelination) can be increased through lifestyle factors like diet, exercise, and cognitive stimulation.

Exercise and Myelin Repair

Exercise is one of the best ways to ignite remyelination and keep your neurons firing quickly and efficiently. In addition to improving functions of the central nervous system, exercise has been shown to mitigate the negative impact of diet on the central nervous system, according to the Mayo Clinic.

This was revealed in a myelin study by Isobel A. Scarisbrick, which showed that a high-fat diet combined with a sedentary lifestyle can reduce myelin-forming cells, contributing to demyelination and associated cognitive decline.

Adding exercise to this high-fat intake, however, has been proven to increase myelin production. Specifically, the seven-week study on mice showed that frequent exercise training has the ability to boost myelin protein expression, even alongside a high-fat diet.

“Our results suggest that consuming high levels of saturated fat in conjunction with a sedentary lifestyle can lead to a reduction in myelin-forming cells. But exercise training can help reverse this process and promote the myelinogenesis necessary to meet increased energy demands,” says Dr. Scarisbrick.

Similar findings were displayed in a study on patients with multiple sclerosis. Published in the Multiple Sclerosis Journal, this study found that measures of overall functioning improved in patients after exercising with free weights, elastic bands, and exercise machines over the course of 24 weeks.

MRI findings also showed that certain areas of the brain thickened, suggesting preservation or regeneration of brain tissue, in 19 of 74 examined brain areas.

Increasing Myelin With Diet

Most people understand that diet plays a critical role in aging. But can it also contribute to increased myelin? A study on gut bacteria in adult mice suggests that probiotics and prebiotics have the ability to alter the gene expression associated with remyelination.

The tests revealed that differences in mice’s microbiomes led to differences in gene expression. Mice that weren’t exposed to certain germs had greater expression in the genes responsible for structuring, regulating, and forming myelin. This suggests that there could be a relationship between gut biome composition and myelin production, and that foods rich in healthy bacteria could aid in achieving the ideal levels.

Dietary supplements have also been shown to boost myelin, as explained by board-certified internist and health care provider Colleen Doherty.

Vitamin D

Vitamin D is thought to aid in remyelination because it assists in regulating the role of oligodendrocytes (which, as we’ve learned, aid in producing myelin). Specifically, vitamin D aids in the maturation of these cells. This nutrient is primarily absorbed through the sun, but it can also be increased by consuming salmon, egg yolks, orange juice, and fortified foods.

Omega-3 Fatty Acids

Increased consumption of omega-3 fatty acids has been associated with improved MS symptoms too. Healthy fats play an important role in longevity and can be found in foods like salmon, chia seeds, flax seeds, soybeans, and walnuts. Healthy fats reduce demyelination because they replicate the fatty texture of myelin.

Cognitive Stimulation and Remyelination

 

Learning new habits and skills can aid in the generation of new myelin in the nervous system, according to Christine Comaford at SmartTribes Institute,

When we practice a new habit, we’re forging new neural pathways in the brain. Repeatedly firing signals down those pathways helps our body understand that this new habit is important.

“Repetition is key — myelin is living tissue: if you stop firing a pathway for 30 days, the myelin will start to break down,” Comaford adds.

She adds that, after persevering through the discomfort of starting a new habit, it’s important to repeat the behavior in quick bursts. Repairing myelin in the body is about quality, not quantity. Practicing for just 5 minutes a day can make all the difference when it comes to forming a new, myelin-boosting habit.

It doesn’t matter so much what activity you’re doing — learning anything from scuba diving to ice hockey to web design can create new pathways in the brain. Rather, it’s the rate at which you do it that determines your body’s ability to experience myelin regeneration.

Melatonin and Myelin Production

Melatonin, the hormone in your body that helps regulate your sleep and wake cycles, plays a role in myelin formation. Specifically, melatonin has been shown to decrease the inflammation that’s associated with demyelination. Exposing yourself to sunshine throughout the day can improve your circadian rhythms and help you achieve more restful sleep.

Adopting bedtime habits such as going to bed at the same time, eliminating late-night snacking, and reducing blue light exposure are all ways to boost melatonin production. Supplementing with magnesium and collagen may also help regulate melatonin production so that you can achieve more consistent sleep schedules that increase myelin-producing nights.

Increasing Myelin for a Healthier Life

While you can’t boost your myelin production in one day, following healthy habits can greatly improve the functioning of your neural pathways. By exercising regularly, learning new skills, and maintaining an active lifestyle, you’ll stay sharper and more mobile as time progresses.

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Exercising, reducing stress, and maintaining a routine are all things that support a healthy sleep schedule. But did you know that nutrition also plays a role in sleep quality? Tryptophan, also known as L-tryptophan, is one nutrient that’s essential for regulating both sleep and mood.

While many people get tryptophan from their normal diets, others have great success when supplementing with L-tryptophan. Whether you’re struggling with sleep or know someone who is, here’s a look at the promising research behind supplementing with L-tryptophan for sleep and overall well-being.

What Is L-Tryptophan?

The body relies on amino acids for important functions like building proteins, regulating neurotransmitters, and regulating immune and metabolic functions.

While not all amino acids are critical to survival, there are nine essential amino acids that the body requires to function at optimal health. Essential amino acids cannot be created by the body and must instead be ingested through diet.

Tryptophan is one of these nine essential amino acids and can be found in common foods like turkey, fish, cheese, chicken, and eggs. Plant-based sources of tryptophan include soy and seeds, like pumpkin and sesame.

All humans unknowingly experience the effects of tryptophan on a daily basis. That’s because tryptophan is responsible for the production of niacin, melatonin, and serotonin. Tryptophan cannot produce niacin unless the body has enough Vitamin B6, Iron, and Riboflavin, yet the role of niacin as a B vitamin means it’s essential for creating energy from food nutrients.

Melatonin is key for regulating healthy sleep-wake cycles, and serotonin plays a role in both sleep and mood regulation. And since tryptophan is an essential amino acid, low L-tryptophan levels can have serious consequences for the mind and body. The primary side effect is decreased sleep quality and increased risk of mental health and mood disorders, including depression.

Benefits of L-Tryptophan Supplements for Sleep

There are many positive effects of L-tryptophan for sleep. Supplementing with L-tryptophan helps improve sleep because it increases melatonin and serotonin, which work in harmony to regulate a person’s sleep-wake cycle.

A large body of research shows that L-tryptophan can be helpful for improving sleep quality in people of all ages. For example, one study sought to determine if a tryptophan-rich breakfast (along with light therapy) could increase melatonin production to induce better sleep.

The results showed that consuming breakfast cereals high in L-tryptophan increased the efficiency of sleep while helping people sleep for a longer amount of time. The research also showed that L-tryptophan decreased sleeplessness during the night and reduced sleep latency — the amount of time it takes to fall asleep.

Similar results were discovered in a study on L-tryptophan and sleep. This research found that taking L-tryptophan supplements twice a day, at night and in the morning, greatly increased melatonin levels. As a result, subjects had improved sleep-wake cycle regulation and slept better.

Another controlled study on newborns tested the effects of 420 mg of L-tryptophan (per 2.2 lbs of body weight) in a bottle. The babies in this study experienced sleepiness sooner and slept for longer than usual, though pediatric use isn’t recommended.

The recommended dose of L-tryptophan for adults is 8-12 grams per day, and this total amount should be divided across three to four doses per day.

L-Tryptophan for Sleep Disorders

It’s clear that L-tryptophan can be helpful for improving sleep, but what about in the instance of chronic sleep disorders?

Scientific studies demonstrate that taking one gram of L-tryptophan before bed can support improved sleep for people with mild insomnia, while up to 15 grams can support severe insomnia, according to psychiatrist James Lake. He adds that people with sleep disorders, such as sleep apnea and narcolepsy, have reported better sleep quality after taking 400-600 grams of 5-HTP before bed.

These findings suggest that L-tryptophan and 5-HTP, respectively, can be used as sleep aids both in people with mild sleep problems and in those with more serious chronic conditions.

Moreover, since sleep and sleep disorders are often associated with mood disorders like stress and anxiety (insomnia can exacerbate stress and stress can cause insomnia), let’s take a look at the promising effects of 5-HTP and L-tryptophan on mental health.

L-Tryptophan for Mental Health and Mood

Anyone considering L-tryptophan for its mental health benefits should also learn about 5-hydroxytryptophan, or 5-HTP. Both tryptophan and 5-HTP are serotonin precursors, meaning they increase serotonin production — the neurotransmitter that supports healthy mood. Yet, 5-HTP is the version of tryptophan before it has been fully transformed into serotonin, meaning it may have a milder effect.

According to a study on 5-HTP, this amino acid “easily crosses the blood-brain barrier and effectively increases central nervous system (CNS) synthesis of serotonin.” This increase in serotonin levels not only supports sleep and mood regulation, but has also been shown to improve depression, anxiety, aggression, mood swings, and muscle pain.

Scientific evidence shows that, due to its positive effect on serotonin production, 5-HTP can also be effective for treating common disorders like chronic headaches, binge eating, and fibromyalgia. Additional studies show that L-tryptophan can be helpful for depression related to menstruation and premenstrual syndrome.

The standard dose for 5-HTP is between 300-500 mg per day, and all other antidepressant medications or serotonin boosters should be stopped immediately when starting 5-HTP. Taking too many supplements that alter this important brain chemical can cause serotonin syndrome. The most common symptoms of serotonin syndrome include restlessness, confusion, rapid heart rate, sweating, muscle tightness, and dilated pupils.

Side Effects of L-Tryptophan

Most people don’t have any side effects when taking L-tryptophan at recommended doses. However, mild symptoms related to L-tryptophan and 5-HTP have been reported, including drowsiness, nausea, constipation, dry mouth, and blurred vision.

The most serious adverse effect has been the onset of eosinophilia-myalgia syndrome, or EMS. This is a rare disorder caused by an increase in white blood cells (eosinophils), which cause inflammation, swelling, cough, behavioral changes, and digestive issues. This became a concern in 1989 when thousands of individuals reported symptoms of EMS after taking a specific brand of L-tryptophan supplement.

This EMS epidemic led to the ban of L-tryptophan supplements in 1990 by the United States Food and Drug Administration (FDA), yet the ban was lifted in 2005. Scientific reports say that the link between L-tryptophan and EMS was actually due to contamination in the L-tryptophan supplement, rather than the intake of L-tryptophan itself. This is due to the fact that there have been no reported cases of L-tryptophan-related EMS since the reintroduction of the supplement in 2005.

Also remember that dietary supplements of L-tryptophan aren’t regulated by the FDA. If you want to add L-tryptophan to your diet, it’s important to consult a health care professional for medical advice related to your specific needs and circumstances.

Supplementing With L-Tryptophan for Sleep

L-tryptophan supplementation has the potential to improve both sleep and mood.

Numerous studies have demonstrated the positive effects of supplementing with L-tryptophan to boost melatonin and serotonin production, both of which help regulate the sleep-wake cycle and improve sleep. Since both L-tryptophan and 5-HTP help boost serotonin, they’ve also been shown to support mental health conditions like depression.

If you’re considering a supplement for better sleep and you’d like to boost your melatonin levels, consider taking L-tryptophan for sleep. Improving your daily rest through nutrition is just one way to better your overall sleep schedule and understand the role of sleep in your mental and physical health.

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Fasting is an age-old practice that is gaining speed in our modern-day world.

From intermittent fasting that can take place every few days or once in a while, to something that is a lifestyle, such as the one-meal-a-day, or OMAD, diet, fasting can take many forms.

Many formerly obese individual credit fasting for extreme weight loss. Others have said it improves overall health and wellness. And while the research backing up fasting regularly is mixed on all sides of the vein, the fact remains that when you don’t eat, things start to happen inside your body that affects your autonomic nervous system, and in turn, your heart rate variability.

Here is what happens to your body when you fast over a long period of time, and as a result, what role those changes play on your heart rate variability.

Your body will break down glycogen

In the beginning of your fast, your body will convert glycogen (sugar) into energy. This is entirely normal following a meal because it’s basically digestion (and your autonomic nervous system at its finest).  However, after about six hours, when you have “officially” begun you fast, your glycogen stores will begin to deplete, and you will become hungry.

Effect on HRV

Because of HRV levels being highly dependent on stress levels, in these beginning stages, your HRV could go high or low depending on your approach to the fast. If you are feeling stressed about being hungry, your HRV will likely be low. However, if you are feeling confident about the results of the fast, and even have the desired outcome, you are likely going to find that your HRV is high, indicating that you are handling the stress on your body quite well.

Your blood glucose level will rise

This may seem wrong because wouldn’t your body lose sugar if it doesn’t have the stores to break it down? And wouldn’t that mean that your blood sugar would go down?

You’d think so, but what actually happens when you fast, is that insulin levels start to drop, triggering a surge of hormones like including noradrenaline and growth hormone to fight against low blood sugar. This, in turn, concentrates the blood with sugar that it pulled from stored sugar that is usually in the liver.

Effect on HRV

According to research, high blood glucose concentration is associated with higher parasympathetic, but lower sympathetic CAM. This means that your body is under more stress to perform its normal functions of the nervous system. If you were to measure these using biometrics, you would likely find your HRV to be on the lower level.

Ketosis will begin

When your body doesn’t have the energy sources to break down new glycogen, it starts to starve and begin the hunt for other things to convert into energy. It will start breaking down fat into fatty acids in order to use them for energy rather than carbs. This is when those looking to use fasting for weight loss begin to see results.

However, due to the fact that the brain cannot use broken down fat for fuel, it turns to ketone bodies for energy. This works for a small time because ketone bodies can’t replace glucose. But after a few days, the ketone bodies build up and a volatile substance called acetone begins to form, lowering the pH of the blood. When this happens, a condition called acidosis develop and lead to coma or even death.

Effect on HRV

At this point — usually around the 48-hour mark —  your body is under stress as it searches for energy sources to survive.  Due to this, your HRV will lower. In fact, a study that took 16 young healthy female volunteers, and had them fast for 48 hours, found that parasympathetic withdrawal was induced with simultaneous sympathetic activation. These findings lead researchers to conclude that the changes in the women’s nervous systems appeared to reflect stress.

However, if your body is used to fasting, or if you have prepared yourself mentally and physically for the fast, the change may not be as significant as it could be otherwise.

If you do notice a significant drop in HRV and begin to feel considerably physical and mental stress, it might be best to abandon the fast at this point.

You’ll have cognitive function impairment

If you continue your fast, your body will be in the process of ketosis and quite possibly acidosis. During these stages, the body starts to break down protein to release amino acids that can convert into glucose. This is done to fuel your brain and suppress hunger.

For those who use fasting as a weight-loss measure, this is the next step that the body takes, and many experts — specifically as it relates to the keto diet —  say that ketosis is not entirely harmful. However, due to the strain on your brain, you may lose some simple brain functions that help you remember things, and carry out simple tasks.

Effect on HRV

The strain on many of your cognitive functions, and the continuing decline in your HRV levels will make it more difficult for your autonomic nervous system to work the way it needs to. You will be less alert and therefore unable to respond well to stressful situations

Fasting isn’t all bad …

The above may seem quite terrible and can be if taken to an extreme level. However, if you use fasting intermittently, your body will likely not have many or any of the negative side effects including those related to HRV.

Do your research on the right fasting approach for your health goals. And as always, check with a medical professional to make sure your body is able to handle the effects — whatever they may be — of a fasting regimen.

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